Process simulation design and techno-economic analysis of production technology of glycerol dehydrogenase

doi:10.3969/j.issn.0438-1157.2013.06.036

CIESC Journal ›› 2013, Vol. 64 ›› Issue (6): 2169-2176.DOI: 10.3969/j.issn.0438-1157.2013.06.036

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Process simulation design and techno-economic analysis of production technology of glycerol dehydrogenase

ZENG Hong^1,4, FANG Baishan^2,3, WANG Paifen⁴, ZHANG Tingting¹

1. School of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian, China;
2. School of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China;
3. National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, Xiamen University, Xiamen 361005, Fujian, China;
4. School of Chemistry and Life Sciences, Quanzhou Normal University, Quanzhou 362000, Fujian, China

Received:2012-11-27 Revised:2013-02-28 Online:2013-06-05 Published:2013-06-05

甘油脱氢酶生产工艺仿真设计与技术经济分析

曾宏^1,4, 方柏山^2,3, 汪排芬⁴, 张婷婷¹

1. 华侨大学化工学院,福建厦门361021;
2. 厦门大学化学化工学院,福建厦门361005;
3. 厦门大学醇醚酯化工清洁生产国家工程实验室,福建厦门361005;
4. 泉州师范学院化学与生命科学学院,福建泉州362000

通讯作者: 方柏山
作者简介:曾宏(1977—),男,博士,副教授。
基金资助:
福建省高校产学合作科技重大项目(2010H6023);福建省教育厅A类科技项目(JA11219);泉州市技术研究与开发基金项目(2010G6)。

Abstract

Abstract: Glycerol dehydrogenase (GDH) is one of the key enzymes for production of dihydroxyacetone (DHA) and 1,3-propanediol (PDO) by the enzymatic method.Based on scale-up of laboratory experiment, the Superpro Designer^® emluator was used to design and simulate the whole process of industrial technology for GDH production, by coupling with costing and economic evaluation of flowsheeting.Simulation results indicated that the process design was reasonable with main process data in agreement with experimental results.The economic analysis showed that raw materials and supplies shared the larger proportion of operating cost reaching 16% and 60% respectively.The expected return on investment (ROI) was to reach 50.48% of approximately 75.36 million CNY project total investments of a 17.9 t·a^-1 plant, as the after-tax profits about 21.08 million CNY·a^-1.

Key words: glycerol dehydrogenase, production technology, process simulation, economic analysis

关键词: 甘油脱氢酶, 生产工艺, 过程模拟, 经济分析

CLC Number:

ZENG Hong, FANG Baishan, WANG Paifen, ZHANG Tingting. Process simulation design and techno-economic analysis of production technology of glycerol dehydrogenase[J]. CIESC Journal, 2013, 64(6): 2169-2176.

曾宏, 方柏山, 汪排芬, 张婷婷. 甘油脱氢酶生产工艺仿真设计与技术经济分析[J]. 化工学报, 2013, 64(6): 2169-2176.

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Process simulation design and techno-economic analysis of production technology of glycerol dehydrogenase

甘油脱氢酶生产工艺仿真设计与技术经济分析

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