Abstract: A morphologically structured model is proposed todescribe the batch fermentation of
lovastatin according to the growthkinetics of filamentous microorganisms. Three kinds of
hyphae areconsidered in the model: actively growing hyphae, non-growing hyphae
anddeactivated hyphae. Furthermore, actively growing hyphae consist ofthree morphological
compartments: apical compartment which gives rise tohyphal tip extension; subapical
compartment which is related to hyphalbranching; and hyphal compartment which is only
responsible forsecondary metabolite formation. The kinetics of mycelial growthmechanism
issummarized and applied in modeling lovastatin fermentation. AMichaelis-Menten kinetic
model with substrate inhibition is proposed forproduct formation. As expected, the model
simulations fit well withexperimental data obtained either from a laboratory scale 10
Lfermenter or from a pilot-plant scale fermenter.

Key words: lovastatin, Aspergillus terreus, filamentousmicroorganism, morphologically structured model, kinetics

摘要： A morphologically structured model is proposed todescribe the batch fermentation of
lovastatin according to the growthkinetics of filamentous microorganisms. Three kinds of
hyphae areconsidered in the model: actively growing hyphae, non-growing hyphae
anddeactivated hyphae. Furthermore, actively growing hyphae consist ofthree morphological
compartments: apical compartment which gives rise tohyphal tip extension; subapical
compartment which is related to hyphalbranching; and hyphal compartment which is only
responsible forsecondary metabolite formation. The kinetics of mycelial growthmechanism
issummarized and applied in modeling lovastatin fermentation. AMichaelis-Menten kinetic
model with substrate inhibition is proposed forproduct formation. As expected, the model
simulations fit well withexperimental data obtained either from a laboratory scale 10
Lfermenter or from a pilot-plant scale fermenter.

关键词: lovastatin;Aspergillus terreus;filamentousmicroorganism;morphologically structured model;kinetics