Effect of rice straw holocellulose on disintegration of aspirin tablets

doi:10.11949/0438-1157.20190466

Abstract

Abstract:

Rice straw holocellulose, prepared from biomass rice straw by SO₃ micro-thermal explore, degradation of lignin and bleaching, was used as tablet disintegrating agent. The performance was evaluated by using it as a tablet disintegrating agent. According to the relevant standards of Chinese Pharmacopoeia (2015 Edition), several characters of rice straw holocellulose, such as surface morphology, specific surface area, pH etc., were detected. Taking aspirin as model drug, the disintegration performance of rice straw holocellulose was determined and compared with commercial microcrystalline cellulose. The results showed that the quality of rice straw holocellulose was in accordance with the relevant regulations of Chinese Pharmacopoeia, and the disintegration of rice straw holocellulose was obviously superior to that of commercial microcrystalline cellulose. The same disintegration effect with 15%—20% microcrystalline cellulose can be attained by using only 3%—5% rice straw holocellulose. This result should be closely owed to the structure and semicellulose of rice straw holocellulose.

Key words: biomass, rice straw, holocellulose, degradation, disintegrant, pharmaceuticals

摘要：

以稻草秸秆为原料，经过SO₃微热爆预处理、木质素降解、漂白等工序制备出了稻草秸秆综纤维素，并将其用作片剂崩解剂进行了性能评价。参照《中国药典》(2015版)中的有关规定，检测了稻草秸秆综纤维素的各项指标；以阿司匹林为模型药物，以市售微晶纤维素为对照，测定了稻草秸秆综纤维素的崩解性能。结果表明，稻草秸秆综纤维素质量符合《中国药典》(2015版)中的相关规定，且崩解性明显优于市售微晶纤维素，可用作片剂崩解剂。在稻草秸秆综纤维素用量为3％~5%时即可达到微晶纤维素用量为15%~20%的崩解效果，这一效果的呈现与稻草秸秆综纤维素的形态结构以及含有半纤维素组分有着密切联系。

关键词: 生物质, 稻草秸秆, 综纤维素, 降解, 崩解剂, 药物

CLC Number:

TB 32

Shuangfeng LI, Huai WANG, Jiali CHEN, Risheng YAO, Huixia ZHU, Xiaojing MA. Effect of rice straw holocellulose on disintegration of aspirin tablets[J]. CIESC Journal, 2019, 70(11): 4420-4427.

李双凤, 王淮, 陈家丽, 姚日生, 朱慧霞, 马晓静. 稻草秸秆综纤维素对阿司匹林片崩解性能的影响[J]. 化工学报, 2019, 70(11): 4420-4427.

Figures/Tables 12

References 39

1	Bährle-Rapp M . Cellulose acetate propionate carboxylate[M]//Springer Lexikon Kosmetik und Körperpflege. Heidelberg, Berlin: Springer, 2007:95.
2	杨维生, 侯永发, 李淑秀 . 电焊条用微晶纤维素的研制与应用[J]. 精细化工, 1995, 12 (1): 44-46.
	Yang W S , Hou Y F , Li S X . Preparation and application of microcrystalline cellulose for electrode [J]. Fine Chemicals, 1995, 12(1): 44-46.
3	Malamataris S , Bin B S , Pilpel N . Plasto-elasticity and tableting of paracetamol, Avicel and other powders[J]. Journal of Pharmacy & Pharmacology, 2011, 36(9): 616-617.
4	Gibis M , Schuh V , Weiss J . Effects of carboxymethyl cellulose (CMC) and microcrystalline cellulose (MCC) as fat replacers on the microstructure and sensory characteristics of fried beef patties[J]. Food Hydrocolloids, 2015, 45: 236-246.
5	张波 . 稻草秸秆微晶纤维素的制备及木质纤维酸解过程中反应的研究[D]. 合肥: 合肥工业大学, 2014.
	Zhang B . Study on preparation of straw microcrystalline cellulose and reaction of lignocellulose during acid hydrolysis [D]. Hefei: Hefei University of Technology, 2014.
6	劲松 . 在存在过氧化氢下水解木材或其它纤维素原料用来生产纤维板: RU2152966[J]. 国际木业, 2003, (5): 44.
	Jin S . In the presence of hydrogen peroxide, water hydrolyzed wood or other cellulose raw materials are used to produce fiberboards: RU2152966 [J]. International Wood Industry, 2003, (5): 44.
7	Zhao X , Zhang L , Liu D . Biomass recalcitrance(Part I): The chemical compositions and physical structures affecting the enzymatic hydrolysis of lignocellulose[J]. Biofuels Bioproducts & Biorefining, 2012, 6(4): 465-482.
8	Menandro L M S , Cantarella H , Kölln O T , et al . Comprehensive assessment of sugarcane straw: implications for biomass and bioenergy production[J]. Biofuels Bioproducts & Biorefining, 2017, 11(3): 488-504.
9	Bari E , Oladi R , Schmidt O , et al . Influence of xylem ray integrity and degree of polymerization on bending strength of beech wood decayed by Pleurotus ostreatus and Trametes versicolor [J]. International Biodeterioration & Biodegradation, 2015, 104: 299-306.
10	Gray M C , Converse A O , Wyman C E . Sugar monomer and oligomer solubility: data and predictions for application to biomass hydrolysis[J]. Applied Biochemistry & Biotechnology, 2003, 105-108(1/2/3): 179.
11	Hisano H , Nandakumar R , Wang Z Y . Genetic modification of lignin biosynthesis for improved biofuel production[J]. Vitro Cellular & Developmental Biology Plant, 2009, 45(3): 306-313.
12	Kumar P , Barrett D M , Delwiche M J , et al . Methods for pretreatment of lignocellulosic biomass for efficient hydrolysis and biofuel production[J]. Industrial & Engineering Chemistry Research, 2009, 48(8): 3713-3729.
13	杨维生 . 微晶纤维素的开发及应用[J]. 化工时刊, 1994, (5): 18-20.
	Yang W S . Development and application of microcrystalline cellulose [J]. Chemical Journal, 1994, (5): 18-20.
14	张云, 张美云, 李金宝, 等 . 麦草秸秆微晶纤维素的制备工艺[J]. 纸和造纸, 2011, 30(4) : 35-37.
	Zhang Y , Zhang M Y , Li J B , et al . Preparation of wheat straw microcrystalline cellulose [J]. Paper and Paper Making, 2011, 30 (4): 35-37.
15	卫婷婷, 纵秋瑾, 姚日生, 等 . 秸秆微晶纤维素用作片剂崩解剂的初步评价[J]. 安徽化工, 2015, 41(3): 24-27.
	Wei T T , Zong Q J , Yao R S , et al . Preliminary evaluation of straw microcrystalline cellulose as tablet disintegrating agent [J]. Anhui Chemical, 2015, 41(3): 24-27.
16	莫小玉, 曲道峰, 韩剑众 . 不同粳米的淀粉及其糊化特性与食用性能的研究[J]. 食品工业科技, 2014, 35(1): 78-82.
	Mo X Y , Qu D F , Han J Z . Studies on starch and gelatinization characteristics and edible properties of different japonica rice [J]. Food Industry Science and Technology, 2014, 35(1): 78-82.
17	刘芳延 . 基于综纤维素制备炭基复合材料及其电化学性能研究[D]. 哈尔滨: 东北林业大学, 2015.
	Liu F Y . Preparation and electrochemical properties of carbon matrix composites based on holocellulose [D]. Harbin: Northeast Forestry University, 2015.
18	Hu C , Zhao Z K . Biorefinery with microbes[M]// The Role of Green Chemistry in Biomass Processing and Conversion. New York: John Wiley & Sons Inc. , 2012: 293-311.
19	高存殿 . 木聚糖基温度/pH响应智能水凝胶的制备及其药物缓释性能研究[D]. 广州: 华南理工大学, 2016.
	Gao C D . Preparation of xylose-based temperature / pH-responsive intelligent hydrogel and its drug release properties [D]. Guangzhou: South China University of Technology, 2016.
20	Liu X , Lin Q , Yan Y , et al . Hemicellulose from plant biomass in medical and pharmaceutical application: a critical review[J]. Current Medicinal Chemistry, 2017, 24: 1-21.
21	Sun J , Tian C , Diamond S , et al . Deciphering transcriptional regulatory mechanisms associated with hemicellulose degradation in Neurospora crassa [J]. Eukaryotic Cell, 2012, 11(4): 482.
22	Farhat W , Venditti R , Ayoub A , et al . Towards thermoplastic hemicellulose: chemistry and characteristics of poly-(ε-caprolactone) grafting onto hemicellulose backbones[J]. Materials & Design, 2018, 153(5): 298-307.
23	张雪琴 . 半纤维素均相化学改性及其材料制备[D]. 广州: 华南理工大学, 2017.
	Zhang X Q . Homogenous chemical modification of hemicellulose and preparation of its materials [D]. Guangzhou: South China University of Technology, 2017.
24	Ragab T I M , Amer H , Mossa A T , et al . Anticoagulation, fibrinolytic and the cytotoxic activities of sulfated hemicellulose extracted from rice straw and husk[J]. Biocatalysis & Agricultural Biotechnology, 2018, 15(21): 86-91.
25	Huang J Q , Qi R T , Tang M R , et al . Study on the separation, chemical structure and immune activity of natural ethmoxylated hemicellulose in bamboo shavings[J]. Journal of Zhejiang University-Science B(Biomedicine & Biotechnology), 2017, 18(2): 138-151+184-185.
26	Whitney S E , Gidley M J , Mcqueen-Mason S J . Probing expansin action using cellulose/hemicellulose composites[J]. Plant Journal, 2010, 22(4): 327-334.
27	潘春雨 . SO₃微热爆/酶催化H₂O₂氧化稻草秸秆制备药用微晶纤维素的研究[D]. 合肥: 合肥工业大学, 2017.
	Pan C Y . Study on the preparation of medicinal microcrystalline cellulose by using SO₃micro-thermal explosion/ enzyme-catalyzed H₂O₂ to oxidize straw and straw[D]. Hefei: Hefei University of Technology, 2017.
28	任海伟, 沈佳莉, 朱晓倩, 等 . 菊芋秸秆制备微晶纤维素的工艺优化及结构表征[J]. 中国食品学报, 2018, (1): 119-127.
	Ren H W , Shen J L , Zhu X Q , et al . Process optimization and structural characterization of microcrystalline cellulose from Jerusalem artichoke straw [J]. Chinese Journal of Food, 2018, (1): 119-127.
29	Sluiter A , Hames B , Ruiz R , et al . Determination of stuctural carbohydrates and lignin in biomass: NREL/TP-510-42618[R]. NREL, 2008
30	国家药典委员会 . 中华人民共和国药典: 四部[M]. 北京: 中国医药科技出版社, 2015: 601.
	National Pharmacopoeia Committee . Pharmacopoeia of the People's Republic of China: Part IV[M]. Beijing: China Pharmaceutical Science and Technology Press, 2015: 601.
31	国家药典委员会 . 中华人民共和国药典: 四部[M]. 北京: 中国医药科技出版社, 2015: 120.
	National Pharmacopoeia Committee . Pharmacopoeia of the People's Republic of China: Part IV[M]. Beijing: China Pharmaceutical Science and Technology Press, 2015: 120.
32	马晓娟, 黄六莲, 陈礼辉, 等 . 纤维素结晶度的测定方法[J]. 造纸科学与技术, 2012, 31(2): 75-78.
	Ma X J , Huang L L , Chen L H , et al . Method for determination of crystallinity of cellulose [J]. Papermaking Science and Technology, 2012, 31(2): 75-78.
33	胡庆轩, 郑怀玉, 林文娟, 等 . 有机粉体流动性的测定[J]. 中国粉体技术, 1999, 5(5): 11-14.
	Hu Q X , Zheng H Y , Lin W J , et al . Determination of flowability of organic powder [J]. China Powder Technology, 1999, 5(5): 11-14.
34	王国栋, 李郁, 张海英 . 黄连超微粉碎前后粉体学和盐酸小檗碱溶出特征的比较[C]//中华中医药学会2013年药房管理分会学术年会. 北中华中医药学会2013年药房管理分会学术年会, 2013: 250-252.
	Wang G D , Li Y , Zhang H Y . Comparison of dissolution characteristics of powdery mildew and berberine hydrochloric acid before and after ultra-fine grinding of Coptis chinensis [C]//Annual Meeting of Pharmacy Management Branch of Chinese Society of Traditional Chinese Medicine in2013. The 2013 Annual Meeting of the Pharmacy Management Branch of the North China Society of Traditional Chinese Medicine, 2013: 250-252.
35	王赟, 许小凯, 杨德义 . 常温压条件下五种变质程度构造煤的超声弹性特征[J]. 中国科学: 地球科学, 2014, (11): 2431-2439.
	Wang Y , Xu X K , Yang D Y . Ultrasonic elastic characteristics of five kinds of metaphorical structural coal under normal temperature and pressure [J]. Chinese Science: Earth Science, 2014, (11): 2431-2439.
36	胡耀波, 王敬丰, 潘复生, 等 . 包套热挤压SiC_p/6066铝基复合材料弹性模量的研究[C]//高技术新材料产业发展研讨会暨材料导报编委会年会. 2007高技术新材料产业发展研讨会, 2007: 296-297.
	Hu Y B , Wang J F , Pan F S , et al . Study on elastic modulus of SiC_p/6066 aluminum matrix composites by hot extrusion [C]//High-tech New Material Industry Development Seminar and Material Guide Annual Meeting of the Editorial Committee. 2007 Symposium on the Development of High-tech New Materials Industry, 2007: 296-297.
37	李凤和 . 基于三氧化硫微热爆法预处理稻草秸秆的过程和优化研究[D]. 合肥: 合肥工业大学, 2012.
	Li F H . Study on the process and optimization of straw pretreatment based on sulfur trioxide micro-thermal explosion method [D]. Hefei: Hefei University of Technology, 2012.
38	Nimz H H . Wood-chemistry, ultrastructure, reactions[J]. Holz als Roh- und Werkstoff, 1984, 42(8): 314.
39	Laureano-Perez L , Teymouri F , Alizadeh H , et al . Understanding factors that limit enzymatic hydrolysis of biomass[J]. Applied Biochemistry & Biotechnology, 2005, 124(1/2/3): 1081-1099.

样品	纤维素含量	半纤维素含量	木质素含量
原稻草秸秆	38.24	21.56	16.4
市售微晶纤维素	96.55	1.76	0.48
稻草秸秆综纤维素	69.59	27.26	0.67

样品	纤维素含量	半纤维素含量	木质素含量
原稻草秸秆	38.24	21.56	16.4
市售微晶纤维素	96.55	1.76	0.48
稻草秸秆综纤维素	69.59	27.26	0.67

性能	市售微晶纤维素	稻草秸秆综纤维素
溶胀体积比（h ₂/h ₁±SD）	1.6 ± 0.15	2.14 ± 0.17
结晶度	65.63%	75.84%
休止角	38.9°	50.7°
堆密度	0.442 g/cm³	0.191 g/cm³

性能	市售微晶纤维素	稻草秸秆综纤维素
溶胀体积比（h ₂/h ₁±SD）	1.6 ± 0.15	2.14 ± 0.17
结晶度	65.63%	75.84%
休止角	38.9°	50.7°
堆密度	0.442 g/cm³	0.191 g/cm³

检验项目	中国药典标准粉状纤维素	中国药典标准微晶纤维素	自制稻草秸秆综纤维素
酸碱度	pH 5.0~7.5	pH 5.0~7.5	pH=5.6
水中溶解物	≤1.5%	≤0.2%	0.19%
醚中溶解物	≤0.15%	≤0.05%	0.14%
炽灼残渣	≤0.3%	≤0.1%	0.21%
干燥失重	≤6.5%	≤7%	5.17%
重金属	≤百万分之十	≤百万分之十	合格
聚合度	≥440	≤350	749
氯化物	无要求	≤0.03%	<0.03%
淀粉	无要求	遇碘不显蓝色	遇碘不显蓝色
电导率	无要求	电导率之差不得过75 μS/cm	71 μS/cm