Progresses of aggregation-induced emission materials in drug delivery and disease treatment

doi:10.11949/0438-1157.20200569

Abstract

Abstract:

Drug delivery systems containing fluorescent probes have the advantage of simultaneous diagnosis and treatment in disease research. Traditional organic fluorescein may exhibit a phenomenon of aggregation caused quenching (ACQ) after aggregation at high concentration. In contrast, it is reported that when a class of fluorescein molecules aggregate in solution, a new phenomenon called aggregation-induced emission (AIE) may occur, because the intramolecular motion is restricted, the non-radiative channel of the molecule is suppressed, and the energy is released in the form of light energy under this circumstance. Drug delivery systems and therapeutic modalities based on AIE fluorescein, termed AIEgen, show promising prospects in detecting and treating life-threatening diseases. This article reviews the research progress of AIE fluorescein in drug delivery, photodynamic and photothermal therapy, and looks forward to the challenges and future directions of research in this field.

Key words: aggregation-induced emission, organic compounds, nanomaterials, photodynamic therapy, photothermal therapy, pharmaceuticals

摘要：

携带荧光探针的药物递送系统在疾病研究中具有同步诊断与治疗的优势。但传统的有机荧光素在高浓度聚集后会出现严重的荧光自淬灭现象，而近年来发现的新型荧光素在高浓度聚集后由于分子内运动受限制，非辐射渠道被抑制，能量以光能的形式释放，产生聚集诱导发光(AIE)现象。基于聚集诱导发光分子的药物递送系统目前已取得良好研究进展，并被用于人类重大疾病的诊治中。本文综述了AIE荧光素用于药物递送以及光动力和光热治疗的研究进展，并对该领域研究面临的挑战和未来方向进行了展望。

关键词: 聚集诱导发光, 有机化合物, 纳米材料, 光动力治疗, 光热治疗, 药物

CLC Number:

TQ 463⁺.3

Yuquan ZHANG, Shuai GUO, Yuhua WENG, Yongfei YANG, Yuanyu HUANG. Progresses of aggregation-induced emission materials in drug delivery and disease treatment[J]. CIESC Journal, 2020, 71(9): 4102-4111.

张玉权, 郭帅, 翁郁华, 杨勇飞, 黄渊余. 聚集诱导发光材料在药物递送与疾病治疗中的研究进展[J]. 化工学报, 2020, 71(9): 4102-4111.

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