自组装肽基纳米材料运载药物和基因的研究进展

doi:10.3969/j.issn.0438-1157.2012.11.002

摘要/Abstract

摘要： 肽基分子自组装以其丰富的自组装驱动力、新颖的自组装体纳米结构、自组装体的特殊功能及良好的生物相容性等,在纳米生物材料、护肤和化妆产品、药物传输释放、组织工程支架材料等方面有着广泛的应用前景。由天然氨基酸组成的自组装短肽具有良好的低细胞毒性,可控的降解性能,高的运载效率及细胞摄取率,同时还具有降低药物的毒副作用等优点。因此,它在作为药物和基因的纳米载药材料方面有着巨大的发展前景。使用自组装肽基材料形成的纳米载体对疏水性抗癌药物、蛋白质药物及基因等进行传递释放已成为生物医药学领域的研究重点,因此,对近年来自组装肽基纳米材料作为药物和基因载体在生物医药学上的研究进展做了综述。

关键词: 肽, 自组装, 纳米材料, 药物运输, 基因载体

Abstract: Due to the unique features,such as rich self-assembly driving forces,novel self-assembly nanostructures,multiple special capabilities and good biocompatibility,short peptide based self-assembled nanomaterials are extremely attractive as building blocks for nano-biomaterials,skin care and cosmetics,drug delivery,tissue engineering scaffolds and many other applications.Because the self-assembling peptides are constituted by natural amino acids,the self-assembled nanomaterials have low cell toxicity,controlled degradation,reduced of side effects of drugs,high delivery efficiency,enhanced drug targeting property,improved gene transfection efficiency and cellular uptake rate.Therefore,there will be promising prospect for the development of peptides used as drug and gene delivery.Using the peptide based self-assembled nanomaterials as the carrier of hydrophobic anticancer drugs,protein drugs,gene and other therapeutic agents has become the research priorities of biomedical science.The progress and applications of the self-assembled peptide based nanomaterials as a loaded carrier in the biomedical science were reviewed. Moreover,the interaction mechanism and characteristics of some bioactive peptide based materials with the therapeutic agents were also introduced.

Key words: peptide, self-assembly, nanomaterials, drug delivery, gene vector

中图分类号:

唐丽丽, 何道航, 观富宜. 自组装肽基纳米材料运载药物和基因的研究进展[J]. 化工学报, DOI: 10.3969/j.issn.0438-1157.2012.11.002.

TANG Lili, HE Daohang, GUAN Fuyi. Progress of peptide based self-assembled nanomaterials for drug and gene delivery[J]. CIESC Journal, DOI: 10.3969/j.issn.0438-1157.2012.11.002.

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