CIESC Journal ›› 2021, Vol. 72 ›› Issue (1): 205-215.DOI: 10.11949/0438-1157.20201075

• Reviews and monographs • Previous Articles     Next Articles

Advances in the synthesis of chiral amines by biocatalytic C—N bond formation

CHENG Yaqi1(),WU Jing1,LIU Liming2,SONG Wei1()   

  1. 1.School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, Jiangsu, China
    2.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
  • Received:2020-07-31 Revised:2020-09-21 Online:2021-01-05 Published:2021-01-05
  • Contact: SONG Wei

生物催化C—N成键反应合成手性胺的研究进展

成雅琪1(),吴静1,刘立明2,宋伟1()   

  1. 1.江南大学药学院,江苏 无锡 214122
    2.江南大学食品科学与技术国家重点实验室,江苏 无锡 214122
  • 通讯作者: 宋伟
  • 作者简介:成雅琪(1996—),女,硕士研究生,1062370924@qq.com
  • 基金资助:
    国家轻工业技术与工程一流学科计划(LITE2018-20);江苏省关键技术研发计划(BE2018623);国家自然科学基金项目(21878126)

Abstract:

Biocatalytic C—N bond formation is mainly used to synthesize chiral amines, which are widely used in the preparation of foods, fine chemicals and pharmaceutical intermediates. Enzymatic production of chiral amines is characterized by high enantioselectivity, conversion and space-time yield. This review mainly introduces three ways of C—N bond formation, which are reductive amination reaction, hydrogen amination reaction and transamination reaction. The related enzymes were summarized according to different reaction types.

Key words: C—N bond, biocatalysis, enzyme, catalyst, reductive amination, hydroamination, transamination

摘要:

生物催化C—N键的成键反应主要是用于合成手性胺类化合物,它广泛应用于食品、精细化学品和药物中间体的制备过程中。酶法生产手性胺具有高对映体选择性、转化率和时空产率的特点。主要介绍了CN键成键的三种方式,分别为还原胺化反应、氢胺化反应和转氨化反应。并根据不同的反应类型对相关的酶进行了归纳总结。

关键词: CN键, 生物催化, 酶, 催化剂, 还原胺化, 氢胺化, 转氨化

CLC Number: