Progress of hemoadsorbent materials for hemoperfusion

doi:10.11949/0438-1157.20201077

Abstract

Abstract:

Hemoperfusion is one type of extracorporeal blood purification therapy. Based on adsorption, the toxins in blood of patients can be efficiently removed by hemoadsorbents. The core of hemoperfusion therapy is the hemoadsorbent materials. The development of high-performance hemoadsorbents will improve the therapeutic efficiency and effect, and reduce or eliminate the severe side effect, thus boosting the development of hemoperfusion technology. Herein, the recent studies of hemoadsorbents are reviewed, including carbon-based materials, polymer-based materials, silica-based materials, molecularly imprinted polymer (MIP)-based materials, adsorption membrane-based materials, novel hemoadsorbents, etc., and the future direction is prospected to provide a guideline for the development of novel hemoadsorbents.

Key words: blood purification, hemoperfusion, adsorbents, hemoadsorbents, adsorption, activated carbon, polymers, antibiofouling

摘要：

血液灌流技术是一种将患者血液引出体外，利用吸附剂材料吸附去除血液中的有害物质，使患者血液得到净化的一种血液净化疗法。其核心是其净化装置中的吸附剂材料。高性能血液灌流吸附剂材料的开发，有助于从根本上改善该疗法对患者的治疗效率和效果，并且减少或根除副反应的发生，从而推动血液灌流技术的发展。综述了近年来血液灌流吸附剂材料的相关研究，包括碳基材料、聚合物基材料、二氧化硅基材料、分子印迹聚合物基材料、吸附膜基材料、新型血液灌流吸附剂等，并对未来血液灌流吸附剂材料的发展进行了展望，以期对新型血液灌流吸附剂的开发提供参考。

关键词: 血液净化, 血液灌流, 吸附剂, 血液净化吸附剂, 吸附, 活性炭, 聚合物, 抗生物污染

CLC Number:

TQ 424.1

Qingsi LI, Lei ZHANG. Progress of hemoadsorbent materials for hemoperfusion[J]. CIESC Journal, 2020, 71(S2): 12-23.

李庆斯, 张雷. 血液灌流吸附剂材料的研究进展[J]. 化工学报, 2020, 71(S2): 12-23.

Figures/Tables 7

Fig.1 Schematic diagram of three adsorption methods

Fig.2 Various hemoadsorbent materials

Fig.3 Adsorption mechanism of zwitterionic polycarboxybetaine (PCB) hydrogel coated activated carbon[9]

Fig.4 Adsorption mechanism of zwitterionic polycarboxybetaine (PCB) hydrogel coated resin[39]

Fig.5 Adsorption mechanism of MXene toward urea[67]

Fig.6 Schematic diagram of adsorption process of PCN-333 and MOF-808[70]

Fig.7 MOF-based antibiofouling hemoadsorbent[71]

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