CIESC Journal ›› 2024, Vol. 75 ›› Issue (4): 1679-1686.DOI: 10.11949/0438-1157.20231417

• Biochemical engineering and technology • Previous Articles     Next Articles

Mitochondria-targeted rhodamine photosensitizers for tumor fluorescence imaging

Shupeng WANG1(), Jianjun DU1,2(), Yao YAO1, Jiangli FAN1,2, Xiaojun PENG1   

  1. 1.State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China
    2.Ningbo Institute of Dalian University of Technology, Ningbo 315016, Zhejiang, China
  • Received:2023-12-31 Revised:2024-02-28 Online:2024-06-06 Published:2024-04-25
  • Contact: Jianjun DU

线粒体靶向的罗丹明衍生物用于肿瘤荧光成像

王书鹏1(), 杜健军1,2(), 姚瑶1, 樊江莉1,2, 彭孝军1   

  1. 1.大连理工大学精细化工国家重点实验室,智能材料导向化学工程前沿科学中心,辽宁 大连 116024
    2.大连理工大学宁波研究院,浙江 宁波 315016
  • 通讯作者: 杜健军
  • 作者简介:王书鹏(1999—),男,硕士研究生,13954534632@mail.dlut.edu.cn
  • 基金资助:
    国家自然科学基金项目(21925802);辽宁滨海实验室项目(LBLB-2023-03);中央高校基本科研业务费专项(CDUTZZLAB601)

Abstract:

Two examples of fluorescent dyes RDMID-C and RDMID-N using rhodamine as the parent were designed and synthesized. The results showed that the dyes exhibited low cytotoxicity, good biocompatibility, and the ability to target mitochondria. The fluorescence dyes showed higher co-localization coefficient with commercial mitochondrial dyes in co-localization experiments, and had longer retention time in tumors, which could be used for tumor fluorescence imaging.

Key words: dyestuffs, fluorescence image, biomedical engineering, biological engineering, biotechnology

摘要:

设计合成了两例以罗丹明为母体的荧光染料RDMID-C和RDMID-N。实验结果表明,上述染料分子具有较低的细胞毒性,良好的生物相容性及靶向细胞线粒体的能力。两例荧光染料在细胞器定位实验中与商业化线粒体染料的共定位系数较高,并在小鼠肿瘤中有较长的滞留时间,可以用于肿瘤荧光成像。

关键词: 染料, 荧光成像, 生物医学工程, 生物工程, 生物技术

CLC Number: