改性聚乳酸-聚乙二醇——多西紫杉醇给药系统的制备

doi:10.3969/j.issn.0438-1157.2014.06.055

化工学报 ›› 2014, Vol. 65 ›› Issue (6): 2357-2362.DOI: 10.3969/j.issn.0438-1157.2014.06.055

• 材料化学工程与纳米技术 • 上一篇下一篇

改性聚乳酸-聚乙二醇——多西紫杉醇给药系统的制备

李瑞端, 张建军, 陈建峰, 滕巍, 李彩霞, 王洁欣

北京化工大学有机无机复合材料国家重点实验室, 北京 100029

收稿日期:2013-09-18 修回日期:2014-02-25 出版日期:2014-06-05 发布日期:2014-06-05
通讯作者: 陈建峰
作者简介:李瑞端（1983- ），女，讲师。
基金资助:
国家自然科学基金项目（51303009），国家高技术研究发展计划项目（2013AA032201）。

Modified polylactic acid loading docetaxel for anticancer drug delivery

LI Ruiduan, ZHANG Jianjun, CHEN Jianfeng, TENG Wei, LI Caixia, WANG Jiexin

State Key Laboratory of Origanic-inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China

Received:2013-09-18 Revised:2014-02-25 Online:2014-06-05 Published:2014-06-05
Supported by:
supported by the National Natural Science Foundation of China (51303009)and the National High Technology Research Development Program of China (2013AA032201).

摘要/Abstract

摘要： 通过丙交酯与氨基碳酸脂共聚来改善聚乳酸的活性，再利用改性后的活性氨基与聚乙二醇接枝共聚来改善聚乳酸的亲水性，将两亲接枝共聚物作为药物载体材料，采用溶剂-反溶剂法制备载有疏水性抗癌药物多西紫杉醇的聚合物纳米粒子，纳米颗粒的尺寸约100 nm。

关键词: 结晶, 合成, 纳米粒子, 聚乳酸, 多西紫杉醇, 共聚物

Abstract: Nanoparticles based on poly(2-amino-1, 3-propanediol carbonic ester-co-lactide)-g-PEG(P(LA-co-CA)-mPEG) were prepared by using the emulsion solvent diffusion method. The copolymer of P (LA-co-CA) was prepared by using ring-opening polymerization with diethylzinc (ZnEt₂) as initiator, and then benzyl oxygen group was taken off to obtain P (LA-co-CA). With the anticancer drug, docetaxel (DTX), as a model drug, the morphology of nanoparticles was characterized with scanning electron microscopy (SEM) and the size and size distribution were determined by dynamic light scattering (DLS). SEM images and DLS results revealed that the particles were spherical in shape and about 100 nm in size, which was suitable for intravenous injection and close to the typically required size under physiological conditions. Thus, nanoparticles of P (LA-co-CA)-mPEG could be used as biodegradable, biocompatible, and cell-specific targetable nano-structured carriers for intracellular delivery of hydrophobic anticancer drugs.

Key words: crystallization, synthesis, nanoparticles, polylactide, docetaxel, copolymer

中图分类号:

李瑞端, 张建军, 陈建峰, 滕巍, 李彩霞, 王洁欣. 改性聚乳酸-聚乙二醇——多西紫杉醇给药系统的制备[J]. 化工学报, 2014, 65(6): 2357-2362.

LI Ruiduan, ZHANG Jianjun, CHEN Jianfeng, TENG Wei, LI Caixia, WANG Jiexin. Modified polylactic acid loading docetaxel for anticancer drug delivery[J]. CIESC Journal, 2014, 65(6): 2357-2362.

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改性聚乳酸-聚乙二醇——多西紫杉醇给药系统的制备

Modified polylactic acid loading docetaxel for anticancer drug delivery

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