关键词: 壳聚糖, 透明质酸, 凝胶, 智能材料

Abstract: Chitosan-hyaluronic acid composite hydrogel was prepared using glutaraldehyde as crosslinking agent（chitosan 15g/L，hyaluronic acid 1g/L，glutaraldehyde 4.8g/L，reacted at room temperature for 24h） to overcome the defects of chitosan hydrogel，such as high fragility，weak viscoelasticity，and low water retentivity. Chitosan and hyaluronan were crosslinked very well within the composite hydrogel and there was no micro phase separation. The composite hydrogel had much better viscoelastic and water-retention properties than chitosan hydrogel. The water retentivity of the composite hydrogel increased with increasing content of hyaluronic acid in the hydrogel. The improvement of water retentivity was more obvious at a high temperature. The composite hydrogel could regularly swell or contract when environmental conditions（temperature，pH，etc.） changed，indicating that this composite hydrogel might be a potential smart material.

Key words: chitosan, hyaluronic acid, gels, smart material