无机纳米药物载体在肿瘤诊疗中的研究进展

doi:10.11949/j.issn.0438-1157.20171179

摘要/Abstract

摘要：

纳米药物作为一种新兴技术，为肿瘤的精确定位和早期诊断、靶向、长效和联合治疗提供了重要的研发平台，为克服传统药物非特异性靶向和非选择性损伤机体组织的瓶颈问题提供了可能。近年来研究者基于量子点、纳米金、纳米介孔硅等无机纳米药物载体设计合成了大量可用于肿瘤诊疗的纳米药物，主要通过“核-壳”结构设计、表面修饰等方法提高纳米药物性能。综述了无机纳米材料作为纳米药物载体在肿瘤诊疗中的应用，详细介绍了纳米药物的设计策略和肿瘤诊疗作用机制，并对未来进行无机纳米药物在肿瘤诊疗中的临床应用进行了展望。

关键词: 纳米粒子, 药物, 药物输送, 光化学, 自组装

Abstract:

Nanomedicine, as an integrated platform, has the potential to accurately monitor tumor for early diagnosis and dramatically improve the targeted, long-lasting and combinational therapy. Compared with traditional therapeutics, nanomedicine would effectively improve the drug accumulationand controlled release in the tumor sites to improve the therapeutic effect. Recently, all kinds of nanomedicines are designed and synthesized for tumor diagnosis and treatment based on inorganic nanocarriers, such as quantum dots, gold nanoparticles, silicon nanoparticles and so on. They might be adjusted and promoted their properties by core-shell structure, surface modification and other strategies. In this review, the inorganic nanometer materials as nano drug carriers applied in tumor diagnosis and treatment were summarized; nano drug design strategies and mechanisms of tumor diagnosis and treatment were introduced in detail, and the future of inorganic nano drugs in tumor diagnosis and treatment of clinical application was prospected.

Key words: nanoparticles, pharmaceuticals, drug delivery, photochemistry, self-assembly

中图分类号:

R730.59

康垚, 王素真, 樊江莉, 彭孝军. 无机纳米药物载体在肿瘤诊疗中的研究进展[J]. 化工学报, 2018, 69(1): 128-140.

KANG Yao, WANG Suzhen, FAN Jiangli, PENG Xiaojun. Progress in inorganic nanomedicine carriers for tumor diagnosis and treatments[J]. CIESC Journal, 2018, 69(1): 128-140.

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