关键词: 盐酸度洛西汀, 生物催化, 酶法拆分, 生物催化不对称合成

Abstract: The incidence of depression showed a clear upward trend in the global. Duloxetine is the better antidepressant drugs，there are some disadvantages on the industry for the full chemical synthesis. Enzyme catalysis has mild reaction condition，environmental friendly and synthetic chiral compounds with high enantioselectivity. Introduction of enzymatic can make up for the chemical synthesis. A review of the progress made in this article，we focused on the enzymatic resolution and bio-catalytic asymmetric synthesis critical enantiomer：1-(tetrahydrothioph-en-2-yl)propan-1-ol derivatives. Meanwhile we summarized their advantages and disadvantages and saw the rosy application prospect. Point out that screening high catalytic and high stability of microorganisms is the main direction of enzymatic technology to achieve industrial application.

Key words: Duloxetine hydrochloride, bio-catalysis, enzyme resolution, asymmetry synthesis with biocatalysis