关键词: 过程强化, 微尺度, 颗粒制备, 膜结晶, 成核, 混合

Abstract:

Crystal particle preparation technology has an irreplaceable role in the fields of chemical engineering, medicine, electronics, biology and so on. The improvement of this technology has always attracted people's attention. In recent years, with the rapid development of chemical process intensification and micro-chemical technology, micro-scale process intensification methods have been widely used in crystal particles preparation and become the research frontier of high-end particle preparation. This article reviews the research progresses of micro-scale enhanced process for particle preparation: focusing on microfluidic module, the principle of microstructure mixer, microfluidic technology to improving micro-mixing efficiency, and its application in nanoparticles drug crystallization and other fields are briefly described. On the micro-force fields, the structure design and visualization study of rotating packed bed, the acoustic cavitation effect represented by ultrasonic field and the application of external force field to the preparation of ultrafine nanoparticles and continuous drug crystallization process are introduced. Further, in view of the micro-scale intensified mass transfer process based on membrane technology, the enhanced mass transfer process of the microporous membrane and the effect of crystal “adhesion-growth-detachment” are analyzed. At the same time, the key structural and process parameters that affect the dispersion mass transfer enhancement process of microporous membrane are explored. The surface renewal mechanism of dense membrane liquid layer to enhance mass transfer and multi-stage membrane operating system that controls preparation of crystalline particles were discussed systematically. Finally, we outline the development trend of crystal particle preparation technology with enhanced mass transfer via microscale processes.

Key words: process intensification, micro-scale, particle preparation, membrane crystallization, nucleation, mixing