化工学报 ›› 2021, Vol. 72 ›› Issue (12): 6254-6261.DOI: 10.11949/0438-1157.20211095
收稿日期:
2021-08-09
修回日期:
2021-11-10
出版日期:
2021-12-05
发布日期:
2021-12-22
通讯作者:
王玉军
作者简介:
谢煜(1994—),女,博士研究生,基金资助:
Received:
2021-08-09
Revised:
2021-11-10
Online:
2021-12-05
Published:
2021-12-22
Contact:
Yujun WANG
摘要:
哌拉西林是一种重要的抗生素,它是利用氨苄西林水溶液和4-乙基-2,3-二氧-1-哌嗪甲酰氯(EDPC)的二氯甲烷溶液在油水界面处反应得到的。利用恒界面池研究界面表观合成反应动力学,确定符合一级反应动力学模型。详细讨论了搅拌速率、比界面积、pH、温度对反应速率的影响,实验结果表明,当搅拌速率大于250 r/min时出现与搅拌强度无关的化学反应控制“坪区”,在“坪区”下,反应速率常数随比界面积、pH、温度增大而增大。通过温度与反应速率常数的关系,得到反应的动力学数据与热力学数据,并通过与密度泛函理论(DFT)结合推导反应机理。
中图分类号:
谢煜, 王玉军. 哌拉西林非均相合成反应动力学的研究[J]. 化工学报, 2021, 72(12): 6254-6261.
Yu XIE, Yujun WANG. A study on kinetics of heterogeneous synthesis of piperacillin[J]. CIESC Journal, 2021, 72(12): 6254-6261.
时间/min | 流动相A/% | 流动相B/% |
---|---|---|
0 | 90 | 10 |
5 | 85 | 15 |
10 | 65 | 35 |
35 | 55 | 45 |
60 | 35 | 65 |
65 | 90 | 10 |
75 | 90 | 10 |
表1 流动相梯度
Table 1 Mobile phase gradient
时间/min | 流动相A/% | 流动相B/% |
---|---|---|
0 | 90 | 10 |
5 | 85 | 15 |
10 | 65 | 35 |
35 | 55 | 45 |
60 | 35 | 65 |
65 | 90 | 10 |
75 | 90 | 10 |
图13 氨苄西林与EDPC合成哌拉西林过程中自由能变化及中间体、过渡态结构
Fig.13 Free energy changes, intermediate and transition state structures during the synthesis of piperacillin with ampicillin and EDPC
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