关键词:

β-环糊精, 脱保护, 催化, 水解, 环己酮肟

Abstract:

Hydrolysis of cyclohexanone oxime promoted by β-cyclodextrin is helpful for protection and deprotection of groups in organic synthesis, thus leading to environment protection.β-Cyclodextrin was used as a catalyst for the hydrolysis of cyclohexanone oxime, since it could activate the substrate and promote its solubility.Various factors including catalyst, reaction temperature, amount of β-cyclodextrin, amount and variety of acid were investigated.β-Cyclodextrin could significantly promote the hydrolysis by interacting with acid, the yield of cyclohexanone was increased from 73% up to 92% by adding β-cyclodextrin at 60℃.Besides, the variety and amount of acids greatly influenced the reaction.Strong acids were much superior to weak acids for the present deprotection reaction.

Key words:

β-环糊精, 脱保护, 催化, 水解, 环己酮肟