化工学报 ›› 2018, Vol. 69 ›› Issue (1): 88-101.DOI: 10.11949/j.issn.0438-1157.20171017

• 综述与专论 • 上一篇    下一篇

降龙涎醚合成研究进展

杨绍祥, 田红玉, 刘永国, 丁瑞, 孙宝国   

  1. 北京工商大学, 北京食品营养与人类健康高精尖创新中心, 北京市食品风味化学重点实验室, 北京 100048
  • 收稿日期:2017-07-31 修回日期:2017-10-24 出版日期:2018-01-05 发布日期:2018-01-05
  • 通讯作者: 孙宝国
  • 基金资助:

    国家重点研发计划项目(2016YFD0400801);国家自然科学基金项目(31571886);“十三五”时期北京市属高校高水平教师队伍建设支持计划青年拔尖人才培育计划(CIT&TCD201804021)。

Research progress in synthesis of (-)-Ambrox

YANG Shaoxiang, TIAN Hongyu, LIU Yongguo, DING Rui, SUN Baoguo   

  1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University, Beijing 100048, China
  • Received:2017-07-31 Revised:2017-10-24 Online:2018-01-05 Published:2018-01-05
  • Contact: 10.11949/j.issn.0438-1157.20171017
  • Supported by:

    supported by the National Key Research and Development Program (2016YFD0400801), the National Natural Science Foundation of China (31571886) and the Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan(CIT&TCD201804021).

摘要:

降龙涎醚具有特殊的龙涎香香气,因其独特的香气特征和特有的定香能力被广泛应用于各种香精配方。目前降龙涎醚的工业生产主要以香紫苏醇、β-二氢紫罗兰酮、金合欢醇类似物为原料进行制备,但这些生产方法从绿色化学的角度来看依然存在诸多的问题。综述了降龙涎醚合成的研究进展,详细阐述了以香紫苏醇为起始原料的合成方法研究进展。其中,以香紫苏醇为起始原料,双氧水作为氧化剂,通过杂多酸盐等催化剂催化合成降龙涎醚,操作简便,污染小,是极具潜力的绿色合成方法。

关键词: 降龙涎醚, 香料, 化学反应, 有机化合物, 污染

Abstract:

(-)-Ambrox has been recognized as the prototype of all ambergris odorants and used as a valuable ingredient in various flavor and fragrance formulations, because of its unique scent and scent fixative function. In current commercial synthesis processes of (-)-Ambrox, major starting raw materials include sclareol, β-dihydroionone and homofarnesol. All these chemical routes have many problems in terms of green chemistry. This review summarized recent progress in Ambrox synthesis and especially expounded progress with sclareol. Among them, one-pot synthesis using sclareol and hydrogen peroxide in the presence of polyoxometalates catalyst has advantages of easy operation and low pollution, which is a potential green synthetic technique.

Key words: Ambrox, flavor, chemical reaction, organic compounds, pollution

中图分类号: