Granulation of spherical particles by crystal agglomeration method

doi:10.11949/0438-1157.20200668

Abstract

Abstract:

Spherical agglomeration technology can prepare spherical agglomerates by coupling crystallization and granulation in a same unit operation, which has the advantages of short process, low production costs and excellent product performance compared with the traditional fluidized bed granulation technology. However, it is still challenging in characterization, mechanism, industrial scale-up, and special crystallizer type. Based on this, this article summarized the characterization techniques and key indicators of spherical crystallization products and mainly introduced the progress of mechanism, mathematical models, new technology and equipment of spherical agglomeration with new ideas for future research and development. Finally, it prospects the development in industrial production, especially in the pharmaceutical field.

Key words: crystallization, agglomeration, fluidized bed, characterization, process control, new methods

摘要：

球形聚结技术能够在同一单元操作中耦合结晶和造粒过程以制备球形晶体。相比于传统流化床造粒技术，该技术具有工艺流程短，生产成本低，产品性能优良的优势，但是同时也面临研究方法不成熟、机理复杂、工业放大和特殊结晶器型等方面的挑战。总结了针对球形结晶产品的表征技术和关键产品指标，介绍了球形聚结过程机理、数学模型和新技术设备的研究进展，并提出关于深化机理、完善模型、开发新设备方面的新思路，最后对其在工业生产尤其是制药领域的发展进行了展望。

关键词: 结晶, 团聚, 流化床, 表征, 过程控制, 新方法

CLC Number:

TQ 028.5

Changyou YU,Bingbing HE,Yanbo LIU,Baohong HOU,Mingyang CHEN,Junbo GONG. Granulation of spherical particles by crystal agglomeration method[J]. CIESC Journal, 2020, 71(11): 4903-4917.

余畅游,何兵兵,刘岩博,侯宝红,陈明洋,龚俊波. 制造球形粒子的晶体聚结方法[J]. 化工学报, 2020, 71(11): 4903-4917.

Figures/Tables 7

Fig.1 SEM images of the product obtained by fluidized bed granulation and spherical agglomeration[24]

Fig.2 Devices of spherical agglomeration and fluidized bed granulation

Fig.3 Spherulite characterization and the relevant test methods

Fig.4 Schematic diagram of spherulite shape characterization parameters

Fig.5 Schematic diagram of spherical agglomeration and influence factor in three-dimensional solvent system[58]

Fig.6 Schematic diagrams of continuous spherical crystallizer

Fig.7 Schematic diagrams of traditional continuous crystallizers

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