CIESC Journal ›› 2021, Vol. 72 ›› Issue (1): 216-228.DOI: 10.11949/0438-1157.20201098

• Reviews and monographs • Previous Articles     Next Articles

Biocatalysis C—C bonding reaction and its application

QI Na1(),SONG Wei1,LIU Liming2,WU Jing1()   

  1. 1.School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, Jiangsu, China
    2.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
  • Received:2020-08-03 Revised:2020-10-21 Online:2021-01-05 Published:2021-01-05
  • Contact: WU Jing

生物催化C—C成键反应及其应用

齐娜1(),宋伟1,刘立明2,吴静1()   

  1. 1.江南大学药学院,江苏 无锡 214122
    2.江南大学食品科学与技术国家重点实验室,江苏 无锡 214122
  • 通讯作者: 吴静
  • 作者简介:齐娜(1997—),女,硕士研究生,1054912091@qq.com
  • 基金资助:
    国家自然科学基金项目(21878126);江苏省科技支撑计划社会发展项目(BE2018623);国家轻工业技术与工程一流学科计划(LITE2018-20)

Abstract:

The CC bond formation reaction is the key reaction to construct the carbon skeleton of organic molecules in organic synthesis. This review presents the key enzymes that catalyze C—C bond formation reactions such as Aldol, Acyloin condensation, Stetter, Pictet-Spengler, etc., and the application progress of those enzymes in the synthesis fine chemicals such as β-hydroxy-α-amino, α-hydroxyketone, 1,4-diketone, β-carboline and tetrahydroisoquinoline in recent years. In addition, this manuscript also describes the application prospects of biocatalysis C—C bond formation reactions to expand the application scope of biocatalysis in chemical production.

Key words: C—C bond, biocatalysis, enzyme, catalyst, fine chemicals, application prospects

摘要:

C—C成键反应是有机合成中构建有机分子碳骨架的关键反应综述了近年来生物催化Aldol、Acyloin condensation、Stetter 、Pictet-Spengler 等C—C成键反应的关键酶制剂,以及这些酶制剂催化合成β-羟基-α-氨基、α-羟基酮、1,4-二酮、β-咔啉、四氢异喹啉等精细化学品的研究进展。此外,还对生物催化C—C成键反应的应用前景进行了展望,从而扩大生物催化在化学品生产中的应用范围。

关键词: C—C成键, 生物催化, 酶, 催化剂, 精细化学品, 应用前景

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