生物矿化及仿生矿化中的信息传递和转化

doi:10.11949/0438-1157.20191225

摘要/Abstract

摘要：

牙齿、骨骼、贝壳等生物矿物具有多级有序的结构和优异的力学性能，是生物矿化过程调控下的矿化结晶产物。生物矿化中的矿物与生物有机基质之间的界面分子识别和结晶调控策略为深入理解化学工程中的“信息传递和转化”范式提供了良好的学习素材。以生物矿化典型无机矿物磷酸钙和碳酸钙体系为例，从生物矿物-溶液界面结构、生物分子与矿物晶面的分子识别、矿物结晶调控三个层面综述了生物矿化的化学调控原理，并从信息传递和转化的化学工程范式出发，分析了生物矿化中分子工程和结晶调控策略。绿色高效的生物矿化过程调控策略有望应用于未来化学工程以解决目前面临的需求倍增和资源短缺的全球性问题。

关键词: 生物模板, 结晶, 分子模拟, 生物矿化, 界面, 纳米结构

Abstract:

Biominerals, such as teeth, bones and shells, have multi-level ordered structure and excellent mechanical properties, and are the crystallization products of mineralization under the control of biomineralization process. The strategies for the control of crystallization in biomineralization would be good examples for a better understanding of the process control and the molecular engineering in chemical engineering. Taking the bio/biomimetic-mineralization of calcium phosphate and calcium carbonate systems as an example, the fundamental principles of biomineralization, such as biominerals/solution interface, the molecular recognitions between biominerals and biomatrix, the advanced molecular control of crystallization and biomimetic fabrications of biominerals-liked hybrid materials are reviewed and discussed in view of the paradigm of“the information transfer and transformation”in chemical engineering, which would be of great helpful for the future development of chemical engineering for solving the global problems of the exponential increased demand in water, energy and commodities with limited resources by using the green and high efficiency biomineralization technology.

Key words: biotemplating, crystallization, molecular simulation, biomineralization, interface, nanostructure

中图分类号:

TQ 132.3

潘海华, 唐睿康. 生物矿化及仿生矿化中的信息传递和转化[J]. 化工学报, 2020, 71(1): 68-80.

Haihua PAN, Ruikang TANG. Information transfer and transformation in bio/biomimetic-mineralization[J]. CIESC Journal, 2020, 71(1): 68-80.

图/表 6

图1 HAP (100) 界面水结构[8]

Fig.1 Structure of water layers on HAP (100) face [8]

图2 方解石 {104} 界面水吸附位点(a) FM-AFM实验结果[14]; (b) XRR实验结果[13]；(c) MD分子模拟结果[15]

Fig.2 Adsorption site for water layers on calcite {104} face

图3 矿物晶体界面水结构与晶体结构的对比(a) HAP (001)晶面; (b) 方解石{104}晶面

Fig.3 Comparison of interfacial water structure with crystal structure

图4 柠檬酸在HAP (100)晶面的吸附位点[26](a) AFM高度图; (b) 吸附位点示意图

Fig.4 Adsorption sites of citrates on HAP (100) surface [26]

图5 SAM膜与方解石{012}面的结构匹配关系的3D模型（不同视角观察）[44]

Fig.5 3D models of calcite crystals nucleated with their {012} faces on SAM on Au(111)[44]

图6 D-和L-Asp在DCPD台阶([101] step A 和 step B)的吸附自由能曲线(a)；Asp在台阶上的稳定吸附构型(b) [12]

Fig.6 Free energy profiles for adsorption of D- and L-Asp on [101] step A and step B (a); Snapshots of stable configurations in adsorbed state at free energy minimum(b)[12]

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