果糖结晶过程优化

doi:10.3969/j.issn.0438-1157.2014.01.032

化工学报 ›› 2014, Vol. 65 ›› Issue (1): 251-257.DOI: 10.3969/j.issn.0438-1157.2014.01.032

果糖结晶过程优化

谢志平¹, 孙登琼¹, 秦亚楠¹, 任日菊¹, 龚俊波^1,2

1 天津大学化工学院, 化学工程联合国家重点实验室, 天津 300072;
2 天津大学药物传递系统天津市重点实验室, 天津 300072

收稿日期:2013-10-08 修回日期:2013-11-27 出版日期:2014-01-05 发布日期:2014-01-05
通讯作者: 龚俊波
作者简介:谢志平（1988-），男，硕士研究生。
基金资助:
国家自然科学基金项目（21176173）；化学工程联合国家重点实验室开放课题（SKL-CHE-11B02）。

Optimization of crystallization process of fructose

XIE Zhiping¹, SUN Dengqiong¹, QIN Yanan¹, REN Riju¹, GONG Junbo^1,2

1 State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
2 Tianjin Key Laboratory of Modern Drug Delivery and High-Efficiency, Tianjin University, Tianjin 300072, China

Received:2013-10-08 Revised:2013-11-27 Online:2014-01-05 Published:2014-01-05
Supported by:
supported by the National Natural Science Foundation of China (21176173) and the State Key Laboratory of Chemical Engineering (SKL-CHE-11B02).

摘要/Abstract

摘要： 通过实验筛选得到适合果糖结晶的混合溶剂，利用中通量结晶仪器Crystalline测定了果糖在水-乙醇（水的摩尔分数为0.39）混合溶剂中的溶解度和介稳区，采用Apelblat方程拟合了溶解度数据。基于热力学数据设计了晶种引晶的果糖冷却结晶工艺，过程优化得到的产品收率可达78.2%以上，纯度可达99%以上，晶体形貌规则，表面光滑，粒度分布窄。当晶体粒径大于100 μm时，利用粒度无关生长的粒数衡算方程建立了果糖连续结晶过程的动力学模型，模型表明晶体生长级数大于成核级数。

关键词: 果糖, 溶解度, 介稳区, 结晶, 动力学, 过程优化

Abstract: Mixed solvent (water-ethanol) was screened out for cooling crystallization of fructose. The instrument, Crystalline was used to determine the solubility and metastable zone of fructose in the binary mixed solvent of water-ethanol (mole fraction of water 0.39). The experimental data of solubility were correlated as a function of temperature by using the Apelblat equation. Based on thermodynamic data of fructose crystallization, the cooling crystallization process was designed and optimized, with over 78.2% yield much higher than that by cooling crystallization in aqueous solution and purity higher than 99%. Compared with the commercially available crystalline fructose, the product crystals were of regular shape, high toughness and narrow crystal size distribution. Laser particle size analyzer, Malvern 3000 was used to determine the continuous crystallization kinetics of fructose, and the crystallization kinetics equation was built by the model of population balance equation proposed by Larson and Randolph and was of size-independent growth with particle size larger than 100μm. The exponent of growth rate was bigger than that of nucleation rate and the crystals tended to grow rather than to nucleate in this size range.

Key words: fructose, solubility, metastable zone, crystallization, kinetics, process optimization

中图分类号:

谢志平, 孙登琼, 秦亚楠, 任日菊, 龚俊波. 果糖结晶过程优化[J]. 化工学报, 2014, 65(1): 251-257.

XIE Zhiping, SUN Dengqiong, QIN Yanan, REN Riju, GONG Junbo. Optimization of crystallization process of fructose[J]. CIESC Journal, 2014, 65(1): 251-257.

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果糖结晶过程优化

Optimization of crystallization process of fructose

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