关键词: 温敏水凝胶, 疏水, 合成, 吸附, 生物医学

Abstract: N-isopropyl acrylamide （NIPAM） is a typical temperature-sensitive hydrogel，which has hydrophilic acylamino and hydrophobic isopropyl groups. Because of its specially reversible swelling/ shrinking properties with temperature changes，it is widely used as a new kind of intelligent material. This review mainly introduces synthesis of hydrophobically modified thermo-sensitive hydrogels. Introduction of hydrophobic monomers can improve its hydrophobic properties and increase its temperature sensitivity，so it has unique application in drug delivery，material separation and biomedical materials. There are some limitations of hydrophobically modified thermo-sensitive hydrogels in theoretical research and actual applications，so we should improve the functional groups of hydrophobic monomers，and synthesize more sensitive and environment-friendly temperature- sensitive hydrogels，expanding the applications to catalysis，water treatment，biological and chemical fields.

Key words: temperature-sensitive gels, hydrophobic, synthesis, adsorption, biomedical