青霉素亚砜结晶生长与成核动力学

doi:10.3969/j.issn.0438-1157.2014.01.023

化工学报 ›› 2014, Vol. 65 ›› Issue (1): 182-189.DOI: 10.3969/j.issn.0438-1157.2014.01.023

青霉素亚砜结晶生长与成核动力学

井丁丁^1,2, 张美景², 王永莉², 王静康²

1 天大方圆工业结晶科技有限公司, 天津 300457;
2 天津大学化工学院, 化学工程联合国家重点实验室, 天津 300072

收稿日期:2013-06-17 修回日期:2013-10-29 出版日期:2014-01-05 发布日期:2014-01-05
通讯作者: 王静康
作者简介:井丁丁（1984-），男，博士。
基金资助:
国家自然科学基金项目（20836005）。

Crystal growth and nucleation kinetics of penicillin sulfoxide

JING Dingding^1,2, ZHANG Meijing², WANG Yongli², WANG Jingkang²

1 Tianda Fangyuan Industrialization Crystallization Technology Co.Ltd., Tianjin 300457, China;
2 State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

Received:2013-06-17 Revised:2013-10-29 Online:2014-01-05 Published:2014-01-05
Supported by:
supported by the National Natural Science Foundation of China(20836005).

摘要/Abstract

摘要： 利用Mydlarz 和 Jones 模型（MJ2），对乙酸丁酯中青霉素亚砜的成核与生长动力学进行研究。通过矩量法对MJ2模型进行处理后，利用晶体产品的粒度分布计算得到青霉素亚砜的生长速率与成核速率，然后利用最小二乘法拟合回归求解出成核与生长动力学方程参数。通过实验设计考察了过饱和度、温度与搅拌速度对青霉素亚砜晶体成核和生长过程的影响。研究表明青霉素亚砜晶体生长速率随过饱和度比的增加呈现指数型增长，确定青霉素亚砜晶体生长属于晶体表面生长控制过程。由于高速搅拌会增加青霉素亚砜晶体的破碎，促进了二次成核过程，随着搅拌速度的增加，晶体生长速率出现小幅下滑，而成核速率则明显升高。青霉素亚砜成核与生长动力学研究将有助于工业生产过程优化。

关键词: 结晶, 动力学, 矩量法, 成核, 晶体生长, 青霉素亚砜

Abstract: The crystal growth and nucleation kinetics of penicillin sulfoxide in butyl acetate were studied with Mydlarz & Jones model, which fits the experimental values best. After the model was treated by moment transformation, the crystal growth and nucleation rates were calculated from the crystal size distribution. The parameters in crystallization kinetic functions were obtained with the least square method. The effects of supersaturation ratio, temperature and agitator speed were examined. In conclusion, the crystal growth of penicillin sulfoxide is controlled by surface growth because the growth rate increases greatly with the increase of supersaturation ratio. High agitator speed results in the breakage of penicillin sulfoxide crystals and improves the secondary nucleation. As a result, crystal growth rate decreases and nucleation rate increases with the increase of agitator speed. The study on crystal growth and nucleation kinetics will be beneficial to the industrial production of penicillin sulfoxide.

Key words: crystallization, kinetics, moment transformation, nucleation, crystal growth, penicillin sulfoxide

中图分类号:

TQ463⁺.3

井丁丁, 张美景, 王永莉, 王静康. 青霉素亚砜结晶生长与成核动力学[J]. 化工学报, 2014, 65(1): 182-189.

JING Dingding, ZHANG Meijing, WANG Yongli, WANG Jingkang. Crystal growth and nucleation kinetics of penicillin sulfoxide[J]. CIESC Journal, 2014, 65(1): 182-189.

参考文献 23

[1]	Mullin J W. Crystallization[M]. Qxford:Butterworth-Heinemann, 1992: 63-64
[2]	Baker P k. Penicillin oxidation process[P]:US, 3904605.1975-06
[3]	Morin R B, Jackson B G, Richard A. Chemistry of cephalosporin antibiotics(Ⅲ): Chemical correlation of penicillin and cephalosporin antibiotics[J]. Journal of the American Chemical Society, 1963, 85(12):1896-1897
[4]	Hanison C R, Philip H. Oxidation of some penicillins and other sulphides by use of a polymer-supported peroxy-acid[J]. Journal of the Chemical Society, Perkin Transactions 1, 1976, 5(21):2252-2253
[5]	Robert B M, Billy G J. Penicillin conversion via sulfoxide[P]:US, 3275625. 1966-9
[6]	Robert B M, Billy G J, Mueller R A, Lavagnino E R, Scanlon W B, Andrews S L. Chemistry of cephalosporin antibiotics(ⅩⅤ): Transformations of penicillin sulfoxide[J]. Synthesis of Cephalosporin Compounds, 1969, 91(6): 1401-1407
[7]	Roelof A L, Bovenberg. Process for the production of 7-ADCA via expanse activity on penicillin[P]:US, 5731165.1998-3
[8]	Roelof A L, Bovenberg. Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA[P]: US, 5795733.1996-5
[9]	Michael J, Lorilee, Phyllis C, John A. Novel bioprocess for preparing 7-ADCA[P]: EP, 0532341.1998-11
[10]	Threlfall T L. Analysis of organic polymorphs[J]. A Review. Analyst., 1995, 120: 2435-2460
[11]	Bransom S H．Factors in the design of continuous crystallizer[J]. British Chemical Engineering, 1960, 5:838-843
[12]	Canning T F, Randolph A D. Some aspects of crystallization theory: system that violate McCabe's ΔL laws[J]. AIChE J., 1967, 13(1):5-10
[13]	Mydlarz J, Jones A G. On modelling the size-dependent growth rate of potassium sulphate in an MSMPR crystallizer[J]. Chemical Engineering Communications, 1989, 90(1):47-56
[14]	Mydlarz J, Jones A G. On the estimation of size-dependent crystal growth rate functions in MSMPR crystallizers[J].Chemical Engineering Journal, 1993, 53(2):125-135
[15]	Abegg C F, Stevens J D, Larson M A. Crystal size distribution in continuous crystallizer when growth rate is size-dependent[J]. AIChE J., 1968, 41(1):118-122
[16]	Randolph A D, White E T. Modelling size dispersion in the prediction of crystal size distribution[J]. Chemical Engineering Science, 1977, 32(9):1067-1076
[17]	Harrington R F, Harrington J L. Field Computation by Moment Methods[M].Oxford: Oxford University Press, 1996:6-10
[18]	Tavare N S. Batch crystallizers[J]. Review in Chemical Engineering, 1991, 7(3/4):259
[19]	Tavare N S, Garside J. Analysis of batch crystallizers[J]. Ind. Eng. Chem. Process Des. Dev., 1980, 19(4):653-665
[20]	Jing Dingding, Wang Jingkang, Wang Yongli. Solubility of penicillin sulfoxide in different solvents[J]. J. Chem. Eng. Data, 2010, 55(1):508-509
[21]	Ding Xuhuai(丁绪怀), Tan Qiu(谈遒). Industry Crystallization(工业结晶)[M]. Beijing: Chemical Industry Press, 1985:98-103
[22]	Lu Jie(陆杰), Wang Jingkang(王静康). Study on reaction crystallization (Ⅱ): Secondary process and mechanism[J]. Chemical Industry and Engineering Progress(化工进展), 1999, 16(1): 58-61
[23]	Myerson A S. Handbook of Industrial Crystallization[M].Boston: Butterworth Heinemann, 2002:53-57

青霉素亚砜结晶生长与成核动力学

Crystal growth and nucleation kinetics of penicillin sulfoxide

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献 23

相关文章 15

编辑推荐

Metrics

本文评价

[1]	金正浩, 封立杰, 李舒宏. 氨水溶液交叉型再吸收式热泵的能量及分析[J]. 化工学报, 2023, 74(S1): 53-63.
[2]	程成, 段钟弟, 孙浩然, 胡海涛, 薛鸿祥. 表面微结构对析晶沉积特性影响的格子Boltzmann模拟[J]. 化工学报, 2023, 74(S1): 74-86.
[3]	肖明堃, 杨光, 黄永华, 吴静怡. 浸没孔液氧气泡动力学数值研究[J]. 化工学报, 2023, 74(S1): 87-95.
[4]	毕丽森, 刘斌, 胡恒祥, 曾涛, 李卓睿, 宋健飞, 吴翰铭. 粗糙界面上纳米液滴蒸发模式的分子动力学研究[J]. 化工学报, 2023, 74(S1): 172-178.
[5]	于宏鑫, 邵双全. 水结晶过程的分子动力学模拟分析[J]. 化工学报, 2023, 74(S1): 250-258.
[6]	范孝雄, 郝丽芳, 范垂钢, 李松庚. LaMnO₃/生物炭催化剂低温NH₃-SCR催化脱硝性能研究[J]. 化工学报, 2023, 74(9): 3821-3830.
[7]	郑佳丽, 李志会, 赵新强, 王延吉. 离子液体催化合成2-氰基呋喃反应动力学研究[J]. 化工学报, 2023, 74(9): 3708-3715.
[8]	汪林正, 陆俞冰, 张睿智, 罗永浩. 基于分子动力学模拟的VOCs热氧化特性分析[J]. 化工学报, 2023, 74(8): 3242-3255.
[9]	杨越, 张丹, 郑巨淦, 涂茂萍, 杨庆忠. NaCl水溶液喷射闪蒸-掺混蒸发的实验研究[J]. 化工学报, 2023, 74(8): 3279-3291.
[10]	傅予, 刘兴翀, 王瀚雨, 李海敏, 倪亚飞, 邹文静, 雷月, 彭永姗. F₃EACl修饰层对钙钛矿太阳能电池性能提升的研究[J]. 化工学报, 2023, 74(8): 3554-3563.
[11]	曾如宾, 沈中杰, 梁钦锋, 许建良, 代正华, 刘海峰. 基于分子动力学模拟的Fe₂O₃纳米颗粒烧结机制研究[J]. 化工学报, 2023, 74(8): 3353-3365.
[12]	李锦潼, 邱顺, 孙文寿. 煤浆法烟气脱硫中草酸和紫外线强化煤砷浸出过程[J]. 化工学报, 2023, 74(8): 3522-3532.
[13]	张蒙蒙, 颜冬, 沈永峰, 李文翠. 电解液类型对双离子电池阴阳离子储存行为的影响[J]. 化工学报, 2023, 74(7): 3116-3126.
[14]	何宣志, 何永清, 闻桂叶, 焦凤. 磁液液滴颈部自相似破裂行为[J]. 化工学报, 2023, 74(7): 2889-2897.
[15]	周继鹏, 何文军, 李涛. 异形催化剂上乙烯催化氧化失活动力学反应工程计算[J]. 化工学报, 2023, 74(6): 2416-2426.