化工学报 ›› 2020, Vol. 71 ›› Issue (1): 122-137.DOI: 10.11949/0438-1157.20191232

• 综述与专论 • 上一篇    下一篇

酶反应精馏耦合技术研究进展

王清莲1(),王晓达1,王红星2,黄智贤1,叶长燊1,邱挺1()   

  1. 1. 福州大学石油化工学院,福建 福州 350116
    2. 天津科技大学化工与材料学院,天津300457
  • 收稿日期:2019-10-23 修回日期:2019-10-29 出版日期:2020-01-05 发布日期:2020-01-05
  • 通讯作者: 邱挺
  • 作者简介:王清莲(1989—),女,博士,wqlian@yeah.net.cn
  • 基金资助:
    国家自然科学基金项目(21808037)

Recent developments in enzymatic reactive distillation coupling technology

Qinglian WANG1(),Xiaoda WANG1,Hongxing WANG2,Zhixian HUANG1,Changshen YE1,Ting QIU1()   

  1. 1. College of Chemical Engineering, Fuzhou University, Fuzhou 350116, Fujian, China
    2. College of Chemical Engineering and Materials Science, Tianjin University of Science & Technology, Tianjin 300457, China
  • Received:2019-10-23 Revised:2019-10-29 Online:2020-01-05 Published:2020-01-05
  • Contact: Ting QIU

摘要:

酶反应精馏是将酶催化反应与精馏过程进行耦合,可有效打破反应化学平衡的限制,提高酶反应转化率和选择性,是一种新型化工过程强化技术。本文分别从酶催化剂及其催化反应机制、酶催化剂装填方式、酶催化反应与精馏耦合型式、酶反应精馏耦合技术的应用案例等方面综述了酶反应精馏耦合技术的研究进展,分析表明:目前酶反应精馏耦合技术的开发尚不成熟,且与化学催化剂催化的反应精馏过程不同,酶反应精馏工艺过程开发还需考虑酶催化反应温度、底物浓度等因素对酶催化活性影响。在后续研究中,可分别从研究体系、酶的固定化技术、酶催化剂装填方式、酶反应精馏理论研究、酶反应精馏耦合工艺开发等方面开展强化研究。

关键词: 酶, 催化, 反应精馏, 过程强化

Abstract:

Enzymatic reactive distillation which combines the enzyme-catalyzed reaction with distillation process can be used to break the limitation of reaction equilibrium and improve the conversion and selectivity effectively. It is a new process intensification technology. In this paper, the progress of enzymatic reactive distillation coupling technology is reviewed from the enzyme catalyst and its catalytic reaction mechanism, the packing method of enzyme catalyst, the coupling mode of enzyme reaction and distillation process and several application cases. It shows that current development of enzyme reactive distillation coupling technique is not mature. The enzyme-catalyzed reactive distillation is quite different with the reactive distillation catalyzed by chemical catalyst. And the influences of parameters such as reaction temperature, substrate concentration on enzyme catalytic activity should be considered. In the future, the strengthening research can be carried out from the research system, enzyme immobilization technology, enzyme catalyst loading mode, enzyme reactive distillation theory research, enzyme reactive distillation coupling process development and so on.

Key words: enzyme, catalysis, reactive distillation, process intensification

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