基于双部分丢弃的模拟移动床产率提高策略

doi:10.11949/0438-1157.20220108

摘要/Abstract

摘要：

在保证产品纯度的情况下，提出一种带额外色谱柱的双部分丢弃策略以提高模拟移动床的产率。通过将工艺点选取在纯提取产品和非纯提余产品区域以增大进料流量，并将由此导致的含较多杂质的提余产品暂时丢弃。丢弃的提余产品作为循环进料通入到一个额外色谱柱中以进一步分离，部分不能达到指定纯度的额外产品被永久丢弃。在模拟移动床和额外色谱柱处分别收集到的产品组成总产品。分析了工艺点的选取、提余产品的积分纯度阈值和额外产品的积分纯度阈值对总产品性能参数的影响。研究结果表明，所提策略能够以较高的回收率利用原料，且能够显著提高分离过程的产率，其分离效果优于传统的模拟移动床工艺和部分丢弃策略。

关键词: 模拟移动床, 色谱, 产率, 平衡理论, 额外色谱柱, 部分丢弃, 优化设计

Abstract:

Under the condition of ensuring the purity of products, an extra-column and binary-partial-discard strategy is proposed to improve the productivity of the simulated moving bed. The process point is selected in the area of pure extract products and non-pure raffinate products to increase the feed flow, and the raffinate products with more impurities is temporarily discarded. The discarded raffinate products is fed as a recycling feed into an extra chromatographic column for further separation, some extra products that cannot reach the specified purity are permanently discarded. In this way, the total products consist of the products collected at the simulated moving bed and the extra chromatographic column respectively. This paper analyzes the effects of the selection of process point, the integral purity threshold of raffinate products and the integral purity threshold of extra products on the performance parameters of total products. The research results show that the proposed strategy can not only use raw materials with high recovery rate, but also can significantly improve the productivity of the simulated moving bed, and its separation effect is better than the conventional simulated moving bed process as well as than the partial-discard strategy.

Key words: simulated moving bed, chromatography, productivity, equilibrium theory, extra-column, partial-discard, optimal design

中图分类号:

TQ 028.8

魏朋, 陈珺, 王志国, 刘飞. 基于双部分丢弃的模拟移动床产率提高策略[J]. 化工学报, 2022, 73(7): 3099-3108.

Peng WEI, Jun CHEN, Zhiguo WANG, Fei LIU. Improved productivity strategy of simulated moving bed based on binary-partial-discard[J]. CIESC Journal, 2022, 73(7): 3099-3108.

图/表 14

图1 线性吸附等温线描述的系统在mⅡ-mⅢ平面上的不同分离区域

Fig.1 Different separation regions on the mⅡ-mⅢ plane of the system described by linear adsorption isotherms

图2 在模拟移动床的循环稳态下提余产品的浓度变化（A为强吸附组分,B为弱吸附组分）

Fig.2 The change of the concentration of the raffinate products under the cyclic steady state of the simulated moving bed

图3 提余产品的纯度变化（蓝色实线表示积分纯度,黑点表示微分纯度）

Fig.3 Purity change of raffinate products

图4 EC-BiPD策略的操作示意图

Fig.4 Schematic diagram of the EC-BiPD strategy

图5 在一个注入周期中额外色谱柱的出口浓度示意图（虚线表示每个注入周期中进料阶段和洗脱阶段的分界线；操作条件:进料中组分A和B的浓度分别为1.17和2.35 g/ml）

Fig.5 Schematic diagram of outlet concentration of the extra column during an injection cycle

表1 模拟移动床的模型参数及初始工艺参数

Table 1 Model parameters and process parameters of the simulated moving bed

模型参数		初始工艺参数
柱分布结构	2-2-2-2	A的进料浓度	0.5 g/ml
组分数	2	B的进料浓度	0.5 g/ml
柱长	53.6 cm	进料液流量	0.0200 ml/s
柱直径	2.6 cm	洗脱液流量	0.0414 ml/s
空隙率	0.38	提取液流量	0.0348 ml/s
轴向扩散系数	0.0381 cm²/s	提余液流量	0.0266 ml/s
A的亨利系数	0.54	循环液流量	0.0981 ml/s
B的亨利系数	0.28	切换时间	1552 s

图6 新工艺点处的流量比(mⅡ,?mⅢ)在mⅡ-mⅢ平面上的分布（p点表示初始工艺点,蓝点表示一组提高产率的工艺点）

Fig.6 The distribution of the flow ratio (mⅡ,?mⅢ) on the mⅡ-mⅢ plane at the new process point

表2 模拟移动床运行在新工艺点时所获得的性能参数

Table 2 The performance parameters obtained when the simulated moving bed runs at the new process point

Run	$m Ⅱ$	$m Ⅲ$	Pu_A/%	Pu_B/%	Re_A/%	Re_B/%
1	0.2850	0.5489	97.61	95.10	90.57	96.50
2	0.2900	0.5539	98.21	94.07	89.42	97.44
3	0.2950	0.5589	98.68	92.93	88.17	98.26
4	0.3000	0.5639	99.07	91.77	86.74	98.89
5	0.3050	0.5689	99.35	90.56	85.22	99.40
6	0.3100	0.5739	99.56	89.16	83.72	99.90
$?$	$?$	$?$	$?$	$?$	$?$	$?$
24	0.4000	0.6639	99.90	67.17	51.04	99.90
25	0.4050	0.6689	99.90	66.37	49.17	99.91
26	0.4100	0.6739	99.91	65.62	47.31	99.93

表2 模拟移动床运行在新工艺点时所获得的性能参数

Table 2 The performance parameters obtained when the simulated moving bed runs at the new process point

Run	$m Ⅱ$	$m Ⅲ$	Pu_A/%	Pu_B/%	Re_A/%	Re_B/%
1	0.2850	0.5489	97.61	95.10	90.57	96.50
2	0.2900	0.5539	98.21	94.07	89.42	97.44
3	0.2950	0.5589	98.68	92.93	88.17	98.26
4	0.3000	0.5639	99.07	91.77	86.74	98.89
5	0.3050	0.5689	99.35	90.56	85.22	99.40
6	0.3100	0.5739	99.56	89.16	83.72	99.90
$?$	$?$	$?$	$?$	$?$	$?$	$?$
24	0.4000	0.6639	99.90	67.17	51.04	99.90
25	0.4050	0.6689	99.90	66.37	49.17	99.91
26	0.4100	0.6739	99.91	65.62	47.31	99.93

图7 模拟移动床运行在新工艺点时得到的提余产品的浓度

Fig.7 The concentration of the raffinate products obtained when the simulated moving bed runs at the new process point

图8 模拟移动床运行在新工艺点时提余产品的积分纯度(蓝线)

Fig.8 The integral purity of the raffinate products when the simulated moving bed runs at the new process point

表3 提余产品在不同纯度阈值下进行部分丢弃后的性能参数

Table 3 Performance parameters of raffinate products after partial-discard under different purity thresholds

Run	纯度阈值/%	纯度/%	回收率/%
1	98.00	98.02	69.91
2	98.10	98.11	69.21
3	98.20	98.23	68.26
4	98.30	98.31	67.56
5	98.40	98.42	66.61
6	98.50	98.51	65.91
7	98.60	98.61	64.96
$?$	$?$	$?$	$?$
15	99.40	99.41	53.92
16	99.50	99.50	51.34
17	99.60	99.60	47.37

表3 提余产品在不同纯度阈值下进行部分丢弃后的性能参数

Table 3 Performance parameters of raffinate products after partial-discard under different purity thresholds

Run	纯度阈值/%	纯度/%	回收率/%
1	98.00	98.02	69.91
2	98.10	98.11	69.21
3	98.20	98.23	68.26
4	98.30	98.31	67.56
5	98.40	98.42	66.61
6	98.50	98.51	65.91
7	98.60	98.61	64.96
$?$	$?$	$?$	$?$
15	99.40	99.41	53.92
16	99.50	99.50	51.34
17	99.60	99.60	47.37

图9 额外产品的出口浓度示意图（实线表示相邻两个注入周期的分界线；虚线表示每个注入周期中进料阶段和洗脱阶段的分界线。操作条件:以表3中Run6下丢弃的提余产品作为额外色谱柱的进料）

Fig.9 Schematic diagram of outlet concentration of extra products

图10 额外产品的积分纯度（操作条件:以表3中Run6下丢弃的提余产品作为额外色谱柱的进料）

Fig.10 Integral purity of extra products

图11 额外产品的积分纯度阈值对总产品性能参数的影响

Fig.11 Effect of integral purity threshold of extra products on performance parameters of total products

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