生物催化C—N成键反应合成手性胺的研究进展

doi:10.11949/0438-1157.20201075

摘要/Abstract

摘要：

生物催化C—N键的成键反应主要是用于合成手性胺类化合物，它广泛应用于食品、精细化学品和药物中间体的制备过程中。酶法生产手性胺具有高对映体选择性、转化率和时空产率的特点。主要介绍了C—N键成键的三种方式，分别为还原胺化反应、氢胺化反应和转氨化反应。并根据不同的反应类型对相关的酶进行了归纳总结。

关键词: C—N键, 生物催化, 酶, 催化剂, 还原胺化, 氢胺化, 转氨化

Abstract:

Biocatalytic C—N bond formation is mainly used to synthesize chiral amines, which are widely used in the preparation of foods, fine chemicals and pharmaceutical intermediates. Enzymatic production of chiral amines is characterized by high enantioselectivity, conversion and space-time yield. This review mainly introduces three ways of C—N bond formation, which are reductive amination reaction, hydrogen amination reaction and transamination reaction. The related enzymes were summarized according to different reaction types.

Key words: C—N bond, biocatalysis, enzyme, catalyst, reductive amination, hydroamination, transamination

中图分类号:

Q 814.9

成雅琪, 吴静, 刘立明, 宋伟. 生物催化C—N成键反应合成手性胺的研究进展[J]. 化工学报, 2021, 72(1): 205-215.

CHENG Yaqi, WU Jing, LIU Liming, SONG Wei. Advances in the synthesis of chiral amines by biocatalytic C—N bond formation[J]. CIESC Journal, 2021, 72(1): 205-215.

图/表 4

图1 N-功能化相关酶的应用

Fig.1 Application of N-functionalized enzymes

图2 胺脱氢酶合成手性胺的应用

Fig.2 Application of amine dehydrogenase to synthesize chiral amines

图3 氢胺化反应的应用

Fig.3 Application of hydroamination reaction

图4 转氨酶合成手性胺的应用

Fig.4 Application of transaminase to synthesize chiral amines

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