熔融结晶的过程强化

doi:10.11949/0438-1157.20210432

摘要/Abstract

摘要：

熔融结晶作为一种绿色高效的分离技术具有选择性高、能量消耗低、无须溶剂参与等优势，但在结晶理论研究、连续化生产、专用结晶器设计和工业放大等方面仍面临挑战。熔融结晶分离效率受物系性质、原料纯度和晶体生长速率限制。因此，熔融结晶过程的合理设计和过程优化对提高熔融结晶技术的能量和过程效率具有重要意义。基于熔融结晶技术在化工分离过程中的实际需求和应用前景，从熔融结晶过程工艺优化、晶体层生长表面设计、过程工艺耦合三方面论述熔融结晶过程中晶体成核、生长的强化方式，为达到高效率、低能耗的熔融结晶分离过程提供可行性指导。最后，概述了目前熔融结晶技术的主要研究焦点并对发展方向进行了展望。

关键词: 分离, 结晶, 成核, 传热, 优化

Abstract:

As a green and efficient separation technology, melt crystallization has the advantages of high selectivity, low energy consumption, and no need for solvents. However, it remains several challenges in theoretical research on crystallization, continuous production, specific targeted crystallizer design and industrial scale-up. Moreover, its separation efficiency is limited by the nature of the system, the purity of raw material and crystal growth rate. Therefore, a reasonable design and process optimization for melt crystallization is of great significance to improve its energy and process efficiency. Based on the actual demand and applying prospects of melt crystallization technology, the intensification methods of crystal nucleation and growth during melt crystallization include three aspects that are: process optimization, surface design of crystal layer growth and coupling technique, which providing the feasible guidance to realize higher efficiency and lower energy consumption. Finally, the critical concerns of melt crystallization are outlined and the development directions are prospected.

Key words: separation, crystallization, nucleation, heat transfer, optimization

中图分类号:

TQ 026.5

景博, 常泽伟, 贾晟哲, 吴送姑, 陈明洋, 高振国, 龚俊波. 熔融结晶的过程强化[J]. 化工学报, 2021, 72(8): 3907-3918.

Bo JING, Zewei CHANG, Shengzhe JIA, Songgu WU, Mingyang CHEN, Zhenguo GAO, Junbo GONG. Process intensification of melt crystallization[J]. CIESC Journal, 2021, 72(8): 3907-3918.

图/表 2

参考文献 81

1	Ulrich J, Bülau H C. Melt Crystallization[M]// Myerson A S. Handbook of Industrial Crystallization. 2nd ed. Woburn: Butterworth-Heinemann, 2002: 161-179.
2	Beckmann W. Crystallization: Basic Concepts and Industrial Applications[M]. Weinheim: Wiley-VCH, 2013: 289-304.
3	Mulvihill M J, Beach E S, Zimmerman J B, et al. Green chemistry and green engineering: a framework for sustainable technology development[J]. Annual Review of Environment and Resources, 2011, 36(1): 271-293.
4	Ulrich J. Is melt crystallization a green technology?[J]. Crystal Growth & Design, 2004, 4(5): 879-880.
5	Wang B M, Li J, Qi Y B, et al. Phosphoric acid purification by suspension melt crystallization: parametric study of the crystallization and sweating steps[J]. Crystal Research and Technology, 2012, 47(10): 1113-1120.
6	König A, Stepanski M, Kuszlik A, et al. Ultra-purification of ionic liquids by melt crystallization[J]. Chemical Engineering Research and Design, 2008, 86(7): 775-780.
7	Ahmad M, Ulrich J. Separation of complex feed streams of a product by layer melt crystallization[J]. Chemical Engineering & Technology, 2016, 39(7): 1341-1345.
8	Shiau L D. The dependence of effective distribution coefficient on growth rate and mass transfer coefficient for p-xylene in solid-layer melt crystallization[J]. Processes, 2020, 8(2): 175.
9	Jia S Z, Jing B, Gao Z G, et al. Melt crystallization of 2, 4-dinitrochlorobenzene: purification and process parameters evaluation[J]. Separation and Purification Technology, 2021, 259: 118140.
10	Liu Q, Li Z J, Liu B S, et al. A new melt crystallization process for efficient purification of chlorobromobenzene[J]. Separation and Purification Technology, 2020, 251: 117367.
11	Beierling T, Ruether F. Separation of the isomeric long-chain aldehydes dodecanal/2-methylundecanal via layer melt crystallization[J]. Chemical Engineering Science, 2012, 77: 71-77.
12	Cong S, Li X G, Wu J, et al. Optimization of parameters for melt crystallization of p-cresol[J]. Chinese Journal of Chemical Engineering, 2012, 20(4): 649-653.
13	Cong S, Liu Y, Li H, et al. Purification and separation of durene by static melt crystallization[J]. Chinese Journal of Chemical Engineering, 2015, 23(3): 505-509.
14	Jiang X B, Li M, He G H, et al. Research progress and model development of crystal layer growth and impurity distribution in layer melt crystallization: a review[J]. Industrial & Engineering Chemistry Research, 2014, 53(34): 13211-13227.
15	Jung J W, Lee H S, Kim K J. Purification of acetic acid wastewater using layer melt crystallization[J]. Separation Science and Technology, 2008, 43(5): 1021-1033.
16	Rich A, Mandri Y, Bendaoud N, et al. Freezing desalination of sea water in a static layer crystallizer[J]. Desalination and Water Treatment, 2010, 13(1/2/3): 120-127.
17	陈亮. 对二甲苯悬浮结晶分离技术进展[J]. 现代化工, 2020, 40(2): 57-61.
	Chen L. Progress in separation of para-xylene by suspension crystallization technology[J]. Modern Chemical Industry, 2020, 40(2): 57-61.
18	Beierling T, Gorny R, Sadowski G. Modeling growth rates in static layer melt crystallization[J]. Crystal Growth & Design, 2013, 13(12): 5229-5240.
19	Ding S P, Huang X, Yin Q X, et al. Heat transfer and its effect on growth behaviors of crystal layers during static layer melt crystallization[J]. Chemical Engineering Science, 2021, 233: 116390.
20	Jiang X B, Xiao W, He G H. Falling film melt crystallization (Ⅲ): Model development, separation effect compared to static melt crystallization and process optimization[J]. Chemical Engineering Science, 2014, 117: 198-209.
21	Yazdanpanah N, Myerson A, Trout B. Mathematical modeling of layer crystallization on a cold column with recirculation[J]. Industrial & Engineering Chemistry Research, 2016, 55(17): 5019-5029.
22	Jiang X B, Hou B H, He G H, et al. Falling film melt crystallization (I): Model development, experimental validation of crystal layer growth and impurity distribution process[J]. Chemical Engineering Science, 2012, 84: 120-133.
23	Jiang X B, Hou B H, Wang J K, et al. Model to simulate the structure of a crystal pillar and optimize the separation efficiency in melt crystallization by fractal theory and technique[J]. Industrial & Engineering Chemistry Research, 2011, 50(17): 10229-10245.
24	Jiang X B, Hou B H, Zhao Y Y, et al. Kinetics study on the liquid entrapment and melt transport of static and falling-film melt crystallization[J]. Industrial & Engineering Chemistry Research, 2012, 51(13): 5037-5044.
25	Jiang X B, Wang J K, Hou B H, et al. Progress in the application of fractal porous media theory to property analysis and process simulation in melt crystallization[J]. Industrial & Engineering Chemistry Research, 2013, 52(45): 15685-15701.
26	Kim Y H, Park L K, Yiacoumi S, et al. Modular chemical process intensification: a review[J]. Annual Review of Chemical and Biomolecular Engineering, 2017, 8: 359-380.
27	König A, Schreiner A. Purification potential of melt crystallisation[J]. Powder Technology, 2001, 121(1): 88-92.
28	Sear R P. Nucleation: theory and applications to protein solutions and colloidal suspensions[J]. Journal of Physics: Condensed Matter, 2007, 19(3): 033101.
29	Kashchiev D, van Rosmalen G M. Review: nucleation in solutions revisited[J]. Crystal Research and Technology, 2003, 38(7/8): 555-574.
30	Haasner T, Kuszlik A K, Stadler R, et al. Surface properties — a key for nucleation in melt crystallization processes[J]. Chemical Engineering & Technology, 2001, 24(9): 873-878.
31	Ma S Y, Li C, Gao J, et al. Artificial neural network prediction of metastable zone widths in reactive crystallization of lithium carbonate[J]. Industrial & Engineering Chemistry Research, 2020, 59(16): 7765-7776.
32	Wang T F, Li X, Dong J X. Ethylene glycol purification by melt crystallization: removal of short-chain glycol impurities[J]. Industrial & Engineering Chemistry Research, 2020, 59(18): 8805-8812.
33	Beierling T, Osiander J, Sadowski G. Melt crystallization of isomeric long-chain aldehydes from hydroformylation[J]. Separation and Purification Technology, 2013, 118: 13-24.
34	Rich A, Mandri Y, Mangin D, et al. Sea water desalination by dynamic layer melt crystallization: parametric study of the freezing and sweating steps[J]. Journal of Crystal Growth, 2012, 342(1): 110-116.
35	Le Page Mostefa M, Muhr H, Plasari E, et al. A purification route of bio-acrylic acid by melt crystallization respectful of environmental constraints[J]. Powder Technology, 2014, 255: 98-102.
36	Wong S Y, Cui Y Q, Myerson A S. Contact secondary nucleation as a means of creating seeds for continuous tubular crystallizers[J]. Crystal Growth & Design, 2013, 13(6): 2514-2521.
37	Agrawal S G, Paterson A H J. Secondary nucleation: mechanisms and models[J]. Chemical Engineering Communications, 2015, 202(5): 698-706.
38	Anwar J, Khan S, Lindfors L. Secondary crystal nucleation: nuclei breeding factory uncovered[J]. Angewandte Chemie International Edition, 2015, 54(49): 14681-14684.
39	Jiang X B, Wang J K, Hou B H. Coarse crystal layer growth and liquid entrapment study with gradient freeze technology[J]. Crystal Research and Technology, 2012, 47(6): 649-657.
40	张纲, 王静康, 熊晖. 沉淀结晶过程中的添加晶种技术[J]. 化学世界, 2002, 43(6): 326-328.
	Zhang G, Wang J K, Xiong H. Seeding technology on the precipitation crystallization process[J]. Chemical World, 2002, 43(6): 326-328.
41	Kubota N, Doki N, Yokota M, et al. Seeding policy in batch cooling crystallization[J]. Powder Technology, 2001, 121(1): 31-38.
42	Choi W S, Kim K J. Separation of acetic acid from acetic acid-water mixture by crystallization[J]. Separation Science and Technology, 2013, 48(7): 1056-1061.
43	Shirai Y, Wakisaka M, Miyawaki O, et al. Effect of seed ice on formation of tube ice with high purity for a freeze wastewater treatment system with a bubble-flow circulator[J]. Water Research, 1999, 33(5): 1325-1329.
44	Matsuoka M, Fukuda T, Takagi Y, et al. Purification of organic solid solutions by melt crystallization: comparison between layer and suspension crystallization[J]. Journal of Crystal Growth, 1996, 166(1/2/3/4): 1035-1039.
45	Fang C, Tang W W, Wu S G, et al. Ultrasound-assisted intensified crystallization of L-glutamic acid: crystal nucleation and polymorph transformation[J]. Ultrasonics Sonochemistry, 2020, 68: 105227.
46	Zeng G S, Li H, Luo S L, et al. Effects of ultrasonic radiation on induction period and nucleation kinetics of sodium sulfate[J]. Korean Journal of Chemical Engineering, 2014, 31(5): 807-811.
47	Nii S, Takayanagi S. Growth and size control in anti-solvent crystallization of glycine with high frequency ultrasound[J]. Ultrasonics Sonochemistry, 2014, 21(3): 1182-1186.
48	朱涛. 超声结晶及其应用[J]. 现代物理知识, 2007, 19(5): 28-29.
	Zhu T. Ultrasonic crystallization and its application [J]. Modern Physics, 2007, 19(5): 28-29.
49	Adachi H, Takano K, Niino A, et al. Solution stirring initiates nucleation and improves the quality of adenosine deaminase crystals[J]. Acta Crystallographica. Section D, Biological Crystallography, 2005, 61(6): 759-762.
50	Yan F W, Zhang S F, Guo C Y, et al. Influence of stirring speed on the crystallization of calcium carbonate[J]. Crystal Research and Technology, 2009, 44(7): 725-728.
51	Lacmann R, Herden A, Mayer C. Kinetics of nucleation and crystal growth[J]. Chemical Engineering & Technology, 1999, 22(4): 279-289.
52	Wang L P. Boron removal and its concentration in aqueous solution through progressive freeze concentration[J]. Environmental Technology, 2017, 38(17): 2224-2232.
53	Yuan W, Zhang L H, Liu Y, et al. Sulfide removal and water recovery from ethylene plant spent caustic by suspension crystallization and its optimization via response surface methodology[J]. Journal of Cleaner Production, 2020, 242: 118439.
54	Yin Y, Yang Y H, de Lourdes Mendoza M, et al. Progressive freezing and suspension crystallization methods for tetrahydrofuran recovery from Grignard reagent wastewater[J]. Journal of Cleaner Production, 2017, 144: 180-186.
55	Shimizu K, Nomura T, Takahashi K. Crystal size distribution of aluminum potassium sulfate in a batch crystallizer equipped with different types of impeller[J]. Journal of Crystal Growth, 1998, 191(1/2): 178-184.
56	陈爱梅, 朱家文, 武斌, 等. 熔融悬浮结晶法提纯湿法磷酸[J]. 化学工程, 2012, 40(8): 52-56.
	Chen A M, Zhu J W, Wu B, et al. Purification of wet-process phosphoric acid by melt suspension crystallization[J]. Chemical Engineering (China), 2012, 40(8): 52-56.
57	Gao Z G, Rohani S, Gong J B, et al. Recent developments in the crystallization process: toward the pharmaceutical industry[J]. Engineering, 2017, 3(3): 343-353.
58	Jiang X B, Lu D P, Xiao W, et al. Membrane assisted cooling crystallization: process model, nucleation, metastable zone, and crystal size distribution[J]. AIChE Journal, 2016, 62(3): 829-841.
59	Mullin J W. Crystallization[M]. 4th ed. Oxford: Butterworth- Heinemann, 2001: 181-214.
60	Kapustenko P O, Kukulka D J, Arsenyeva O P. Intensification of heat transfer processes[C]// PRES'15: Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction. Milano, 2015: 1729-1734.
61	原宇航, 钱志刚, 马建学, 等. 一种用于降膜结晶器的结晶管: 101745248B[P]. 2012-12-12.
	Yuan Y H, Qian Z G, Ma J X, et al. Crystallization tube for falling-film crystallizer: 101745248B[P]. 2012-12-12.
62	Le Page Mostefa M, Muhr H, Biget A, et al. Intensification of falling film melt crystallization process through micro and milli-structured surfaces[J]. Chemical Engineering and Processing: Process Intensification, 2015, 90: 16-23.
63	Artusio F, Pisano R. Surface-induced crystallization of pharmaceuticals and biopharmaceuticals: a review[J]. International Journal of Pharmaceutics, 2018, 547(1/2): 190-208.
64	Grosfils P, Lutsko J F. Impact of surface roughness on crystal nucleation[J]. Crystals, 2020, 11(1): 4.
65	Beierling T, Micovic J, Lutze P, et al. Using complex layer melt crystallization models for the optimization of hybrid distillation/melt crystallization processes[J]. Chemical Engineering and Processing: Process Intensification, 2014, 85: 10-23.
66	Verdoes D, Arkenbout G J, Bruinsma O S L, et al. Improved procedures for separating crystals from the melt[J]. Applied Thermal Engineering, 1997, 17(8/9/10): 879-888.
67	van der Gun M A, Bruinsma O S L, van Rosmalen G M. Pastille purification in a gravity wash column[J]. Chemical Engineering Science, 2001, 56(7): 2381-2388.
68	Kim K J, Kim J K, Lee H S, et al. Process for separating and recovering naphthalene from raffinate produced from pyrolysis of naphtha via suspension crystallization, melting crystallization and partial melting steps: KR717386B1[P]. 2007-03-04.
69	王彦飞,黄岐汕,彭南玉,等. 耦合熔融结晶制备高纯联苯的方法: 104311380A[P]. 2015-01-28.
	Wang Y F, Huang Q S, Peng N Y, et al. Method for preparing high-purity biphenyl by coupling and melt crystallization: 104311380A[P]. 2015-01-28.
70	Konig A, Ulrich J. Method and apparatus for purifying chemical substances: US5810892 A [P]. 1998-09-22.
71	van der Gun M A, Bruinsma O S L, Jansens P J. Production, characterization and purification of polycrystalline particles[J]. Chemical Engineering Research and Design, 2003, 81(8): 904-915.
72	van der Gun M A, Bruinsma O S L, Jansens P J. Purification of polycrystalline ε-caprolactam particles[J]. Chemical Engineering Science, 2005, 60(1): 201-211.
73	Kiss A A. Distillation technology - still young and full of breakthrough opportunities[J]. Journal of Chemical Technology & Biotechnology, 2014, 89(4): 479-498.
74	Li C L, Zhou Y W, Su W Y, et al. Research progress of hybrid distillation/crystallization technology[J]. Chemical Engineering & Technology, 2018, 41(10): 1894-1904.
75	Franke M B, Nowotny N, Ndocko E N, et al. Design and optimization of a hybrid distillation/melt crystallization process[J]. AIChE Journal, 2008, 54(11): 2925-2942.
76	Ban H, Cheng Y W, Wang L J, et al. Preparation of high-purity 2,6-naphthalenedicarboxylic acid from coal tar distillate[J]. Chemical Engineering & Technology, 2019, 42(6): 1188-1198.
77	叶青, 裘兆蓉, 钟秦, 等. 用精馏-降膜结晶耦合技术提纯对二氯苯[J]. 精细化工, 2005, 22(5): 362-364.
	Ye Q, Qiu Z R, Zhong Q, et al. Purification of dichlorobenzene by distillation-falling film crystallization hybrid processes[J]. Fine Chemicals, 2005, 22(5): 362-364.
78	Micovic J, Beierling T, Lutze P, et al. Design of hybrid distillation/melt crystallisation processes for separation of close boiling mixtures[J]. Chemical Engineering and Processing: Process Intensification, 2013, 67: 16-24.
79	Kunde C, Michaels D, Micovic J, et al. Deterministic global optimization in conceptual process design of distillation and melt crystallization[J]. Chemical Engineering and Processing: Process Intensification, 2016, 99: 132-142.
80	Ahmad N A, Leo C P, Ahmad A L, et al. Membranes with great hydrophobicity: a review on preparation and characterization[J]. Separation & Purification Reviews, 2015, 44(2): 109-134.
81	Kontos S S, Katrivesis F K, Constantinou T C, et al. Implementation of membrane filtration and melt crystallization for the effective treatment and valorization of olive mill wastewaters[J]. Separation and Purification Technology, 2018, 193: 103-111.

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