离子液体中采用AGET ATRP法制备MCC-g-PGMA

doi:10.11949/j.issn.0438-1157.20141846

化工学报 ›› 2015, Vol. 66 ›› Issue (S1): 365-369.DOI: 10.11949/j.issn.0438-1157.20141846

• 材料化学工程与纳米技术 • 上一篇下一篇

离子液体中采用AGET ATRP法制备MCC-g-PGMA

袁淼, 唐二军, 杜凯迪, 刘洪, 周剑, 刘少杰, 赵地顺

河北科技大学化学与制药工程学院, 河北省药物化工工程技术中心, 河北石家庄 050018

收稿日期:2014-12-15 修回日期:2014-12-24 出版日期:2015-06-30 发布日期:2015-06-30
通讯作者: 唐二军
基金资助:
国家自然科学基金项目(21304030);河北省自然科学基金项目(B2013208183)。

Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids

YUAN Miao, TANG Erjun, DU Kaidi, LIU Hong, ZHOU Jian, LIU Shaojie, ZHAO Dishun

School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, Hebei, China

Received:2014-12-15 Revised:2014-12-24 Online:2015-06-30 Published:2015-06-30
Supported by:
supported by the National Natural Science Foundation of China (21304030) and the Natural Science Foundation of Hebei Province (B2013208183).

摘要/Abstract

摘要：

在氯化1-烯丙基-3-甲基咪唑([AMIM]Cl)离子液体中, 采用AGET ATRP技术, 以VC为还原剂、CuBr₂/乙二胺为催化体系, 成功制备了微晶纤维素接枝聚甲基丙烯酸缩水甘油酯(MCC-g-PGMA)分子。研究表明:[AMIM]Cl对微晶纤维素有较好的溶解性, 最佳反应条件为GMA/乙二胺/CuBr₂/VC摩尔比为100:4:1:1, 反应温度25℃, 反应时间4 h, 接枝效率可达54.56%, 分子量分布较窄为1.48。通过FT-IR、TEM和SEM测试表明:成功合成了MCC-g-PGMA接枝共聚物分子, PGMA接枝微晶纤维素后表面形态变得粗糙, 接枝共聚物在丙酮溶液中可自组装成150～200 nm的球形结构, 在药物载体领域具有良好的应用潜能。

关键词: 离子液体, 甲基丙烯酸缩水甘油酯, AGET ATRP, 微晶纤维素, 分子合成, 聚合物

Abstract:

The MCC-g-PGMA was synthesized by AGET ATRP in ionic liquid [AMIM]Cl. Vitamin C was used as the reducing agent and CuBr₂/ethanediamine was the catalytic system. The experiment proved that microcrystalline cellulose can well dissolve in [AMIM]Cl. Optimum mole ratio of GMA/ethanediamine/ CuBr₂/VC were attained at 100:4:1:1. The temperature and reaction time were 25℃ and 4 h. The grafting efficiency was as high as 54.56% and the distribution of molecular weight of MCC-g-PGMA was 1.48. FT-IR proved that the MCC-g-PGMA graft copolymer was successfully synthesized by AGET ATRP in [AMIM]Cl. SEM showed the surface of MCC was changed and became coarse after PGMA grafted to MCC. It has a perfect application potential in the field of drug carrier.

Key words: ionic liquid, methyl methacrylate, AGET ATRP, microcrystalline cellulose, molecular synthesis, polymers

中图分类号:

TQ032.4

袁淼, 唐二军, 杜凯迪, 刘洪, 周剑, 刘少杰, 赵地顺. 离子液体中采用AGET ATRP法制备MCC-g-PGMA[J]. 化工学报, 2015, 66(S1): 365-369.

YUAN Miao, TANG Erjun, DU Kaidi, LIU Hong, ZHOU Jian, LIU Shaojie, ZHAO Dishun. Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids[J]. CIESC Journal, 2015, 66(S1): 365-369.

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离子液体中采用AGET ATRP法制备MCC-g-PGMA

Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids

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